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Actomyosin modulation by peroxynitrite

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dc.contributor.authorTiago, Teresa
dc.contributor.authorSilva, D.
dc.contributor.authorSantos, Ana
dc.contributor.authorAureliano, M.
dc.contributor.authorGutiérrez-Merino, Carlos
dc.date.accessioned2012-06-26T11:02:05Z
dc.date.available2012-06-26T11:02:05Z
dc.date.issued2007
dc.description.abstractIn the present work we address the oxidative modifications accounting for the structural and functional impairment of the actomyosin complex under the oxidative stress mediated by peroxynitrite (ONOO-). Experiments on purified myosin and actin have shown that submicromolar ONOO- concentrations produce strong inhibition of the F-actin stimulated myosin ATPase activity. The peroxynitrite-induced actomyosin impairment correlated with structural modifications that decrease the thermal stability of both actin and myosin leading to partially unfolded states. The results suggest a major role for the highly reactive cysteines on actin and on myosin and also for some critical methionines on G-actin. 3-nitrotyrosine does not contribute significantly to the observed functional alterations.por
dc.identifier.urihttp://hdl.handle.net/10400.1/1310
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherMedimondpor
dc.subjectActomyosinpor
dc.subjectPeroxynitritepor
dc.titleActomyosin modulation by peroxynitritepor
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F20777%2F2004/PT
oaire.citation.endPage190por
oaire.citation.startPage187por
oaire.citation.titleEuropean Meeting of the Society for Free Radical Research International, Source: Free Radicals, Health and Lifestylepor
oaire.fundingStreamSFRH
person.familyNameSantos
person.familyNameAureliano
person.familyNameGutierrez-Merino
person.givenNameAna
person.givenNameManuel
person.givenNameCarlos
person.identifier584146
person.identifier.ciencia-idAA14-3490-DC5E
person.identifier.orcid0000-0001-6136-8376
person.identifier.orcid0000-0003-4858-3201
person.identifier.orcid0000-0003-3673-7007
person.identifier.ridA-4422-2009
person.identifier.ridI-3283-2012
person.identifier.ridK-4574-2014
person.identifier.scopus-author-id8272373100
person.identifier.scopus-author-id6603412860
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublication55a8ac2d-f486-43f9-ac23-451a628a9150
relation.isAuthorOfPublicationbb413661-7edd-4b57-8338-33889cfd05db
relation.isAuthorOfPublication1edd3bda-28a9-4d7f-a404-f867f72ddefa
relation.isAuthorOfPublication.latestForDiscovery1edd3bda-28a9-4d7f-a404-f867f72ddefa
relation.isProjectOfPublication7710d769-9931-452e-86ad-8b31dddca6d1
relation.isProjectOfPublication.latestForDiscovery7710d769-9931-452e-86ad-8b31dddca6d1

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