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A comparative study on biological properties and chemical profiles of different solvent extracts from Centaurea bingoelensis, an endemic plant of Turkey

2021-03Journal article Restricted access
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dc.contributor.authorUysal, Ahmet
dc.contributor.authorZengin, Gokhan
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorPicot-Allain, Carene
dc.contributor.authorJeko, Jozsef
dc.contributor.authorCziaky, Zoltan
dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorAk, Gunes
dc.contributor.authorPolat, Ridvan
dc.contributor.authorUrusan, Zeynep
dc.contributor.authorSinan, Kouadio Ibrahime
dc.contributor.authorCustódio, Luísa
dc.date.accessioned2021-09-08T10:58:04Z
dc.date.available2021-09-08T10:58:04Z
dc.date.issued2021-03
dc.description.abstractThis study focused on the biological evaluation and chemical characterization of Centaurea bingoelensis, an endemic plant to Turkey. Different solvent extracts (hexane, dichloromethane (DCM), ethyl acetate (EA), methanol, hydro-methanol, and water extracts) were prepared. The antioxidant, enzyme inhibitory, antimicrobial and cytotoxic activities were investigated. The hydro-methanol extract, possessing high phenolic content (41.57 mg gallic acid equivalent (GAE)/g extract), showed highest reducing capacity (136.87 and 82.16 mg Trolox equivalent [TE]/g extract, for cupric reducing antioxidant capacity and ferric reducing antioxidant power, respectively) and radical scavenging potential (70.72 and 76.53 mg TE/g extract, against 2,2-diphenyl-1-picryl-hydrazyl and 2,2' -azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), respectively). Ultra performance liquid chromatography - tandem mass spectrometer (UHPLC/MS/MS) analysis revealed the presence of 67 and 62 compounds in the methanolic and water extracts, respectively. According to the broth microdilution results, DCM and EA extracts showed significant antimicrobial activity with Sarcina lutea being the most sensitive bacterium to the extracts (MIC = 0.19 (DCM) and 0.097 mg/mL (EA)). Most extracts showed promising antifungal activity against Candida albicans. The methanol extract was most toxic against human hepatocarcinoma (HepG2) cells, and also significantly reduced the cell viability of the non-tumoral murine bone marrow stromal (S17) cells. This study has provided valuable scientific data on this endemic plant which can be considered as a promising candidate for the development of novel phyto-pharmaceuticals.
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.procbio.2021.01.023
dc.identifier.issn1359-5113
dc.identifier.urihttp://hdl.handle.net/10400.1/17019
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.subjectCentaurea
dc.subjectAntioxidants
dc.subjectNatural agents
dc.subjectExtracts
dc.subjectBiological activities
dc.subject.otherBiochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Engineering
dc.titleA comparative study on biological properties and chemical profiles of different solvent extracts from Centaurea bingoelensis, an endemic plant of Turkey
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage324
oaire.citation.startPage315
oaire.citation.titleProcess Biochemistry
oaire.citation.volume102
person.familyNameRodrigues
person.familyNameCustódio
person.givenNameMaria João
person.givenNameLuísa
person.identifierR-004-VNG
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication12c32925-de9e-4289-bdd5-1d655d7a278c
relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
relation.isAuthorOfPublication.latestForDiscovery12c32925-de9e-4289-bdd5-1d655d7a278c

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