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Biopotential of sea cucumbers (echinodermata) and tunicates (chordata) from the western coast of portugal for the prevention and treatment of chronic illnesses

2020-10-30Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg14:Proteger a Vida Marinha
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorCarletti, Alessio
dc.contributor.authorCardoso, Carlos
dc.contributor.authorJuliao, Diana
dc.contributor.authorArteaga, Jorge L.
dc.contributor.authorChainho, Paula
dc.contributor.authorDionísio, Maria Ana
dc.contributor.authorSales, Sabrina
dc.contributor.authorGaudêncio, Maria J.
dc.contributor.authorFerreira, Inês
dc.contributor.authorAfonso, Cláudia
dc.contributor.authorLourenço, Helena
dc.contributor.authorCancela, M. Leonor
dc.contributor.authorBandarra, Narcisa M.
dc.contributor.authorGavaia, Paulo
dc.date.accessioned2026-02-24T11:00:19Z
dc.date.available2026-02-24T11:00:19Z
dc.date.issued2020-10-30
dc.description.abstractIn the present work, we aimed to explore the potential of two groups of marine invertebrates—sea cucumbers (Echinodermata) and ascidians (Chordata)—as sources of antiinflammatory, anti-oxidant, and osteogenic compounds with potential to be used as pharmaceuticals and nutraceuticals for the treatment and prevention of chronic diseases. 24 extracts (ethanol, water, and ethyl acetate) from 4 species of sea cucumbers and 4 species of tunicates were produced and screened in vitro for their anti-inflammatory and anti-oxidant activities and in vivo for osteogenic activity through an assay using zebrafish larvae. Our results showed that ethanolic extracts presented anti-oxidant and anti-inflammatory activity, which revealed to be stronger in the ascidians. The osteogenic activity, which provides evidence of the bioactive potential of these organisms in preventing chronic disorders causing low bone density, was found to be strong in one species of ascidians and 3 of holothurians. This study demonstrates the high potential of extracts from these marine organisms for using as nutraceuticals in the prevention of chronic bone disorders.eng
dc.description.sponsorshipMAR02.02.01-FEAMP-0004
dc.identifier.doi10.3390/iecn2020-06994
dc.identifier.urihttp://hdl.handle.net/10400.1/28233
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationAlgarve Centre for Marine Sciences
dc.relationMarine and Environmental Sciences Centre
dc.relation.ispartofFirst International Electronic Conference on Nutrients, Microbiota and Chronic Disease
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectChronic diseases
dc.subjectNutraceuticals
dc.subjectNatural compounds
dc.subjectSea cucumbers
dc.subjectTunicates
dc.subjectAntiinflammatory
dc.subjectAnti-oxidant
dc.subjectOsteogenic
dc.titleBiopotential of sea cucumbers (echinodermata) and tunicates (chordata) from the western coast of portugal for the prevention and treatment of chronic illnesseseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04292%2F2020/PT
oaire.citation.conferenceDate2020
oaire.citation.titleProceedings
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCarletti
person.familyNameCancela
person.familyNameGavaia
person.givenNameAlessio
person.givenNameM. Leonor
person.givenNamePaulo
person.identifier.ciencia-idBE18-E938-C489
person.identifier.ciencia-idB619-FC16-D007
person.identifier.orcid0000-0003-2593-2499
person.identifier.orcid0000-0003-3114-6662
person.identifier.orcid0000-0002-9582-1957
person.identifier.ridA-6470-2011
person.identifier.scopus-author-id6507104377
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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