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Biochemical and molecular responses of the Mediterranean mussel (Mytilus galloprovincialis) to short-term exposure to three commonly prescribed drugs

2021Journal article Restricted access
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dc.contributor.authorPes, Katia
dc.contributor.authorFriese, Annika
dc.contributor.authorCox, Cymon J.
dc.contributor.authorLaizé, Vincent
dc.contributor.authorFernández, Ignacio
dc.date.accessioned2021-07-07T21:02:41Z
dc.date.available2021-07-07T21:02:41Z
dc.date.issued2021
dc.description.abstractPharmaceuticals represent a group of emerging contaminants. The short-term effect (3 and 7 days) of warfarin (1 and 10 mg L-1), dexamethasone (0.392 and 3.92 mg L-1) and imidazole (0.013 and 0.13 mg L-1) exposure was evaluated on mussels (Mytilus galloprovincialis). Total antioxidant status, glutathione reductase, glutathione peroxidase (GPx) and superoxide dismutase enzyme activities, and the expression of genes involved in the xenobiotic response (ATP binding cassette subfamily B member 1 (abcb1) and several nuclear receptor family J (nr1j) isoforms), were evaluated. All nr1j isoforms are suggested to be the xenobiotic receptor orthologs of the NR1I family. All drugs increased GPx activity and altered the expression of particular nr1j isoforms. Dexamethasone exposure also decreased abcb1 expression. These findings raised some concerns regarding the release of these pharmaceuticals into the aquatic environment. Thus, further studies might be needed to perform an accurate environmental risk assessment of these 3 poorly studied drugs.pt_PT
dc.description.sponsorshipPortuguese Foundation for Science and Technology: UIDB/04326/2020; European Social Fund, "The European Social Fund invests in your future" through the Ramon y Cajal contract from the Plan Estatal de Investigacion Cientifica y Tecnica e Innovacion 2017-2020: RYC2018-025337-Ipt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.marenvres.2021.105309pt_PT
dc.identifier.issn0141-1136
dc.identifier.urihttp://hdl.handle.net/10400.1/16743
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAnimalspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectGlutathione Peroxidasept_PT
dc.subjectMytiluspt_PT
dc.subjectPharmaceutical preparationspt_PT
dc.subjectWater pollutantspt_PT
dc.subjectChemicalpt_PT
dc.titleBiochemical and molecular responses of the Mediterranean mussel (Mytilus galloprovincialis) to short-term exposure to three commonly prescribed drugspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage105309pt_PT
oaire.citation.titleMarine Environmental Researchpt_PT
oaire.citation.volume168pt_PT
person.familyNamePes
person.familyNameFriese
person.familyNameCox
person.familyNameLaizé
person.givenNameKatia
person.givenNameAnnika
person.givenNameCymon
person.givenNameVincent
person.identifier.ciencia-id531A-DC47-297B
person.identifier.ciencia-id6B15-9771-1D04
person.identifier.orcid0000-0002-0459-4622
person.identifier.orcid0000-0001-8576-8059
person.identifier.orcid0000-0002-4927-979X
person.identifier.orcid0000-0001-9565-9198
person.identifier.ridD-1303-2012
person.identifier.ridB-4463-2008
person.identifier.scopus-author-id7402112716
person.identifier.scopus-author-id6602982778
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication21d44f44-a6ed-41fd-ad50-658b2df55097
relation.isAuthorOfPublicationb30cfb47-e9ef-44a0-b3fe-2556ce314b5a
relation.isAuthorOfPublication82c3689c-60b6-440d-9d7b-49e6dbd6861b
relation.isAuthorOfPublicationb51cd3d5-7ee4-47d8-9bc4-b3e297aa222f
relation.isAuthorOfPublication.latestForDiscovery82c3689c-60b6-440d-9d7b-49e6dbd6861b

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