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Fucoidan from Fucus Vesiculosus: Evaluation of the impact of the Sulphate content on Nanoparticle production and Cell toxicity

2023-02-07Journal article Open Access
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dc.contributor.authorFLÓREZ-FERNÁNDEZ, NOELIA
dc.contributor.authorPontes, Jorge Filipe
dc.contributor.authorGuerreiro, Filipa
dc.contributor.authorAfonso, Inês T.
dc.contributor.authorLollo, Giovanna
dc.contributor.authorTorres, Maria Dolores
dc.contributor.authorDomínguez, Herminia
dc.contributor.authorM Rosa, Ana
dc.contributor.authorGrenha, Ana
dc.date.accessioned2023-02-27T13:10:47Z
dc.date.available2023-02-27T13:10:47Z
dc.date.issued2023-02-07
dc.date.updated2023-02-24T14:08:20Z
dc.description.abstractThe composition of seaweeds is complex, with vitamins, phenolic compounds, minerals, and polysaccharides being some of the factions comprising their structure. The main polysaccharide in brown seaweeds is fucoidan, and several biological activities have been associated with its structure. Chitosan is another marine biopolymer that is very popular in the biomedical field, owing to its suitable features for formulating drug delivery systems and, particularly, particulate systems. In this work, the ability of fucoidan to produce nanoparticles was evaluated, testing different amounts of a polymer and using chitosan as a counterion. Nanoparticles of 200–300 nm were obtained when fucoidan prevailed in the formulation, which also resulted in negatively charged nanoparticles. Adjusting the pH of the reaction media to 4 did not affect the physicochemical characteristics of the nanoparticles. The IC50 of fucoidan was determined, in both HCT−116 and A549 cells, to be around 160 µg/mL, whereas it raised to 675–100 µg/mL when nanoparticles (fucoidan/chitosan = 2/1, w/w) were tested. These marine materials (fucoidan and chitosan) provided features suitable to formulate polymeric nanoparticles to use in biomedical applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarine Drugs 21 (2): 115 (2023)pt_PT
dc.identifier.doi10.3390/md21020115pt_PT
dc.identifier.eissn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.1/19143
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntioxidantpt_PT
dc.subjectCell proliferationpt_PT
dc.subjectChitosanpt_PT
dc.subjectFucoidanpt_PT
dc.subjectFucus vesiculosuspt_PT
dc.subjectNanoparticlespt_PT
dc.subjectRheologypt_PT
dc.titleFucoidan from Fucus Vesiculosus: Evaluation of the impact of the Sulphate content on Nanoparticle production and Cell toxicitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.citation.issue2pt_PT
oaire.citation.startPage115pt_PT
oaire.citation.titleMarine Drugspt_PT
oaire.citation.volume21pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFlórez-Fernández
person.familyNamePontes
person.familyNameRosa da Costa
person.familyNameGrenha
person.givenNameNoelia
person.givenNameJorge Filipe
person.givenNameAna M
person.givenNameAna
person.identifier305029
person.identifier.ciencia-idC21E-5E21-0A08
person.identifier.ciencia-idCB16-5CBD-8B89
person.identifier.ciencia-idA418-A85E-5DB1
person.identifier.ciencia-id091C-0D58-7225
person.identifier.orcid0000-0002-2666-2315
person.identifier.orcid0000-0002-6447-0242
person.identifier.orcid0000-0003-0225-9537
person.identifier.orcid0000-0002-2136-1396
person.identifier.ridI-1131-2015
person.identifier.ridE-2165-2012
person.identifier.ridH-1392-2017
person.identifier.scopus-author-id57192869367
person.identifier.scopus-author-id57195033461
person.identifier.scopus-author-id53986075100
person.identifier.scopus-author-id8607930100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication5fe61715-ceb9-459e-8e65-7fe0253514f4
relation.isAuthorOfPublication3388102a-dcde-4918-81d6-b7b27f34f3ba
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