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Lipid-based nanoformulations for drug delivery: an ongoing perspective

2024-10-26Journal article Open access
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dc.contributor.authorRehman, Mubashar
dc.contributor.authorTahir, Nayab
dc.contributor.authorSohail, Muhammad Farhan
dc.contributor.authorQadri, Muhammad Usman
dc.contributor.authorDuarte, Sofia O. D.
dc.contributor.authorBrandão, Pedro
dc.contributor.authorEsteves, Teresa
dc.contributor.authorJaved, Ibrahim
dc.contributor.authorFonte, Pedro
dc.date.accessioned2025-01-10T11:49:31Z
dc.date.available2025-01-10T11:49:31Z
dc.date.issued2024-10-26
dc.description.abstractOils and lipids help make water-insoluble drugs soluble by dispersing them in an aqueous medium with the help of a surfactant and enabling their absorption across the gut barrier. The emergence of microemulsions (thermodynamically stable), nanoemulsions (kinetically stable), and self-emulsifying drug delivery systems added unique characteristics that make them suitable for prolonged storage and controlled release. In the 1990s, solid-phase lipids were introduced to reduce drug leakage from nanoparticles and prolong drug release. Manipulating the structure of emulsions and solid lipid nanoparticles has enabled multifunctional nanoparticles and the loading of therapeutic macromolecules such as proteins, nucleic acid, vaccines, etc. Phospholipids and surfactants with a well-defined polar head and carbon chain have been used to prepare bilayer vesicles known as liposomes and niosomes, respectively. The increasing knowledge of targeting ligands and external factors to gain control over pharmacokinetics and the ever-increasing number of synthetic lipids are expected to make lipid nanoparticles and vesicular systems a preferred choice for the encapsulation and targeted delivery of therapeutic agents. This review discusses different lipids and oil-based nanoparticulate systems for the delivery of water-insoluble drugs. The salient features of each system are highlighted, and special emphasis is given to studies that compare them.eng
dc.identifier.doi10.3390/pharmaceutics16111376
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/10400.1/26605
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relationInstitute for Bioengineering and Biosciences
dc.relationInstitute for Bioengineering and Biosciences
dc.relationInstitute for Health and Bioeconomy
dc.relationEgas Moniz Interdisciplinary Research Center
dc.relation.ispartofPharmaceutics
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectLiposomes
dc.subjectSLN
dc.subjectTargeting
dc.subjectControlled release
dc.subjectSolubility enhancement
dc.subjectVaccine
dc.subjectHydrophobic
dc.subjectPeptide
dc.subjectSelf-emulsifying
dc.titleLipid-based nanoformulations for drug delivery: an ongoing perspectiveeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardTitleEgas Moniz Interdisciplinary Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04585%2F2020/PT
oaire.citation.issue11
oaire.citation.startPage1376
oaire.citation.titlePharmaceutics
oaire.citation.volume16
oaire.fundingStream6817 - DCRRNI ID
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oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFonte
person.givenNamePedro
person.identifier.ciencia-id2410-123D-3385
person.identifier.orcid0000-0002-1115-9282
person.identifier.ridK-3215-2013
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