Publication
CITED Proteins in cardiac development and lifelong heart function
| dc.contributor.author | Bragança, José | |
| dc.contributor.author | Cabrita Pinto, Rute Luísa | |
| dc.contributor.author | Vairinho Ventura, Igor | |
| dc.contributor.author | Ferreira, Silvana | |
| dc.contributor.author | Marreiros, António | |
| dc.date.accessioned | 2026-01-04T23:30:59Z | |
| dc.date.available | 2026-01-04T23:30:59Z | |
| dc.date.issued | 2025-11-07 | |
| dc.description.abstract | The CITED proteins function as transcriptional modulators that are essential for vertebrate development. These proteins interact with numerous partners, notably transcription factors and co-activators. The hallmark of the CITED family is their conserved carboxy-terminal domain, which interacts strongly with the CBP/p300 co-activators. The expression of CITED genes is detected early during embryogenesis within embryonic and foetal regions critical for cardiac morphogenesis, among other developmental processes. Notably, CITED2 loss of function is strongly associated with congenital heart malformations in mice and zebrafish embryos, as well as congenital heart disease (CHD) in humans, whereas other CITED family members are not critical for cardiogenesis. Emerging evidence implicates CITED2 and CITED4 in regulating heart physiological adaptations and protective responses to pathological stress. This review provides a detailed analysis of CITED proteins and their interactors, focusing on CITED-target genes relevant for cardiogenesis and heart disease. We also highlight recent findings indicating that CITED2 and CITED4 may be instrumental for the development of novel therapeutic strategies to mitigate CHD and preserve adult cardiac function. | eng |
| dc.description.sponsorship | J.B., R.L.C.P., I.V., S.F. and A.M were supported by Fundação para a Ciência e Tecnologia (FCT) with the grant reference 2024.14693.PEX; R.L.C.P. received an FCT PhD fellowship with the reference 2023.00861.BD; J.B., R.P, I.V., A.M. and S.F. were supported by the Algarve Biomedical Center (ABC) award—“Bolsa de investigação translacional—José Mariano Gago by ABC”, Santa Casa Misericórdia Lisboa for the “Prémio Nunes Correa Verdades de Faria” award 2025 in the category C “Progresso no Tratamento das Doenças do Coração”, and the European University of the Seas Alliance for an award in the context of the SEA-EU 2.0 Erasmus+ Project 101089757 to J.B. | |
| dc.identifier.doi | 10.3390/jpm15110542 | |
| dc.identifier.issn | 2075-4426 | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/28050 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation.ispartof | Journal of Personalized Medicine | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | CITED1 | |
| dc.subject | CITED2 | |
| dc.subject | CITED4 | |
| dc.subject | Heart development | |
| dc.subject | Heart diseases | |
| dc.subject | Congenital heart disease | |
| dc.title | CITED Proteins in cardiac development and lifelong heart function | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 11 | |
| oaire.citation.startPage | 542 | |
| oaire.citation.title | Journal of Personalized Medicine | |
| oaire.citation.volume | 15 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| person.familyName | Bragança | |
| person.familyName | Cabrita Pinto | |
| person.familyName | Vairinho Ventura | |
| person.familyName | Ferreira | |
| person.givenName | José | |
| person.givenName | Rute Luísa | |
| person.givenName | Igor | |
| person.givenName | Silvana | |
| person.identifier | 2785254 | |
| person.identifier.ciencia-id | AC1D-FA9D-F66F | |
| person.identifier.ciencia-id | 221A-6F43-797D | |
| person.identifier.ciencia-id | E31C-FB3B-FDF9 | |
| person.identifier.orcid | 0000-0001-9566-400X | |
| person.identifier.orcid | 0000-0001-8192-5803 | |
| person.identifier.orcid | 0009-0001-4402-4480 | |
| person.identifier.orcid | 0009-0000-2913-5388 | |
| person.identifier.scopus-author-id | 6602220001 | |
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