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Intranasal drug delivery for treatment of Alzheimer's disease

2021-04Journal article Restricted access
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dc.contributor.authorFonseca, Leonor Cancela
dc.contributor.authorLopes, Joao
dc.contributor.authorVieira, Joao
dc.contributor.authorViegas, Claudia
dc.contributor.authorOliveira, Claudia S.
dc.contributor.authorHartmann, Rafael P.
dc.contributor.authorFonte, Pedro
dc.date.accessioned2021-09-08T10:58:05Z
dc.date.available2021-09-08T10:58:05Z
dc.date.issued2021-04
dc.description.abstractThe Alzheimer's disease is a neurodegenerative condition with severe consequences interfering with patient quality of life. It is characterized as a progressive and irreversible brain disorder hampering memory and thinking, affecting the capacity to perform daily tasks leading to physical and cognitive incapacitation. The conventional treatment occurs by the oral route, but it presents relevant drawbacks such as low bioavailability, fast metabolism, limited brain exposure, and undesirable side effects. The intranasal route has been proposed as a promising alternative to deliver drugs and improve the Alzheimer's disease treatment. Still, there is not a clear alternative delivery system available in the market with advantageous bioavailability and safety. The aim of this review is to perform an overview on the strategies for drug intranasal delivery for Alzheimer's disease treatment. The advantages and disadvantages of this delivery route and the delivery systems developed so far are discussed. A special focus is given on the use of permeation enhancers, the types of intranasal drug delivery devices, as well as possible toxicity concerns.
dc.description.sponsorshipFCT-Foundation for Science and TechnologyPortuguese Foundation for Science and Technology [UIDB/04326/2020, UIDB/04565/2020]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1007/s13346-021-00940-7
dc.identifier.issn2190-393X
dc.identifier.urihttp://hdl.handle.net/10400.1/17024
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSPRINGER HEIDELBERG
dc.relationAlgarve Centre for Marine Sciences
dc.relationInstitute for Bioengineering and Biosciences
dc.subjectNanoparticle
dc.subjectProtein
dc.subjectPermeation enhancer
dc.subjectBlood-brain barrier
dc.subjectCentral nervous system
dc.subjectNeurodegenerative
dc.subject.otherInstruments & Instrumentation; Research & Experimental Medicine; Pharmacology & Pharmacy
dc.titleIntranasal drug delivery for treatment of Alzheimer's disease
dc.typejournal article
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04565%2F2020/PT
oaire.citation.conferencePlaceUniv Santiago Compostela, Santiago, SPAIN
oaire.citation.endPage425
oaire.citation.issue2
oaire.citation.startPage411
oaire.citation.titleDrug Delivery and Translational Research
oaire.citation.title13th Spanish Portuguese Conference on Controlled Drug Delivery
oaire.citation.volume11
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCancela
person.familyNameLopes
person.familyNameFonte
person.givenNameM. Leonor
person.givenNameJoao
person.givenNamePedro
person.identifier.ciencia-id591B-6DEB-ECF9
person.identifier.ciencia-id2410-123D-3385
person.identifier.orcid0000-0003-3114-6662
person.identifier.orcid0000-0001-5670-2069
person.identifier.orcid0000-0002-1115-9282
person.identifier.ridK-3215-2013
person.identifier.scopus-author-id35094054800
person.identifier.scopus-author-id55146900200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
rcaap.typeconferenceObject
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