Effects of domain connection and disconnection on the yields of in-plane bimolecular reactions in membranes

Melo, E. C. C.; Lourtie, I. M. G.; Sankaram, M. B.; Thompson, T. E.; Vaz, Winchil

http://hdl.handle.net/10400.1/11249

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
EFFECTS OF DOMAIN CONNECTION AND DISCONNECTION ON THE YIELDS OF INPLANE BIMOLECULAR REACTIONS IN MEMBRANES.pdf		620.04 KB	Adobe PDF	Download

Send Feedback

Authors

Abstract(s)

It has recently been shown (Vaz, W.L.C., E.C.C. Melo, and T.E. ThomPson. 1989. Biophys. J. 56:869-875; 1990. Biophys. J. 58:273-275) that in lipid bilayer membranes in which ordered and disordered phases coexist, the ordered phase can form a two-dimensional reticular structure that subdivides the coexisting disordered phase into a disconnected domain structure. Here we consider theoretically the yields of bimolecular reactions between membrane-localized reactants, when both the reactants and products are confined to the disordered phase. It is shown that compartmentalization of reactants in disconnected domains can lead to significant reductions in reaction yields. The reduction in yield was calculated for classical bimolecular processes and for enzyme-catalyzed reactions. These ideas can be used to explain certain experimental observations.

Keywords

2-phase phosphatidylcholine bilayer Fluid-phase connectivity Translational diffusion Lateral diffusion Mitochondrial 2-component Transitions Mobility Model