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Effects of domain connection and disconnection on the yields of in-plane bimolecular reactions in membranes

1992-12Journal article Open access
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dc.contributor.authorMelo, E. C. C.
dc.contributor.authorLourtie, I. M. G.
dc.contributor.authorSankaram, M. B.
dc.contributor.authorThompson, T. E.
dc.contributor.authorVaz, Winchil
dc.date.accessioned2018-12-07T14:52:53Z
dc.date.available2018-12-07T14:52:53Z
dc.date.issued1992-12
dc.description.abstractIt has recently been shown (Vaz, W.L.C., E.C.C. Melo, and T.E. ThomPson. 1989. Biophys. J. 56:869-875; 1990. Biophys. J. 58:273-275) that in lipid bilayer membranes in which ordered and disordered phases coexist, the ordered phase can form a two-dimensional reticular structure that subdivides the coexisting disordered phase into a disconnected domain structure. Here we consider theoretically the yields of bimolecular reactions between membrane-localized reactants, when both the reactants and products are confined to the disordered phase. It is shown that compartmentalization of reactants in disconnected domains can lead to significant reductions in reaction yields. The reduction in yield was calculated for classical bimolecular processes and for enzyme-catalyzed reactions. These ideas can be used to explain certain experimental observations.
dc.description.sponsorshipNIGMS NIH HHS [GM-23573, GM-14628]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/S0006-3495(92)81735-6
dc.identifier.issn0006-3495
dc.identifier.urihttp://hdl.handle.net/10400.1/11249
dc.language.isoeng
dc.peerreviewedyes
dc.publisherBiophysical Society
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject2-phase phosphatidylcholine bilayer
dc.subjectFluid-phase connectivity
dc.subjectTranslational diffusion
dc.subjectLateral diffusion
dc.subjectMitochondrial
dc.subject2-component
dc.subjectTransitions
dc.subjectMobility
dc.subjectModel
dc.titleEffects of domain connection and disconnection on the yields of in-plane bimolecular reactions in membranes
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1512
oaire.citation.issue6
oaire.citation.startPage1506
oaire.citation.titleBiophysical Journal
oaire.citation.volume63
person.familyNameVaz
person.givenNameWinchil
person.identifier.orcid0000-0002-3797-4330
person.identifier.ridN-4320-2013
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication026f80ca-8d1a-4e4d-a38a-9247ae26ff10
relation.isAuthorOfPublication.latestForDiscovery026f80ca-8d1a-4e4d-a38a-9247ae26ff10

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