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Molecular mechanisms of lignans in lowering blood pressure and anti-obesity effects: a review

2026-01-16Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg02:Erradicar a Fome
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorDas, Gitishree
dc.contributor.authorGonçalves, Sandra
dc.contributor.authorHeredia, José Basilio
dc.contributor.authorLeyva-López, Nayely
dc.contributor.authorRomano, Anabela
dc.contributor.authorParamithiotis, Spiros
dc.contributor.authorShin, Han-Seung
dc.contributor.authorPatra, Jayanta Kumar
dc.date.accessioned2026-02-20T10:05:37Z
dc.date.available2026-02-20T10:05:37Z
dc.date.issued2026-01-16
dc.description.abstractLignans are naturally occurring compounds found in a wide variety of plant species, including flaxseed, soybean, pumpkin seed, broccoli, sesame seed, and some berries. Lignans have been used for centuries in both food and traditional herbal medicine. Recently, numerous new lignans and lignan derivatives with diverse biological properties have been identified. Lignans are considered promising for human health due to their hydrogendonating antioxidant activity together with their ability to complex divalent transition metal cations. They have demonstrated beneficial effects for cardiovascular disease, as well as in maintaining blood glucose levels, supporting cardiac health, promoting anti-obesity effects, decreasing the risk of renal diseases, enhancing brain function, improving skin and gut health, among others. This review explores the biosynthesis and biological effects of lignans, with a particular focus on their antihypertensive and anti-obesity properties, as well as the molecular mechanisms involved. It also highlights recent advances in sustainable lignan extraction techniques that are suitable for human use. The mechanisms underlying these bioactivities are thought to involve hormonal metabolism and availability, antioxidant action, modulation of angiogenesis, and more. However, further research is needed to fully elucidate the molecular pathways through which lignans exert their therapeutic effects. Overall, lignans from various plant sources hold significant potential for application in functional foods, dietary supplements, and pharmaceutical products aimed at preventing and managing a range of health conditions, including hypertension and obesity.eng
dc.description.sponsorshipCEECINST/00052/2021
dc.identifier.doi10.3390/foods15020336
dc.identifier.issn2304-8158
dc.identifier.urihttp://hdl.handle.net/10400.1/28197
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationMediterranean Institute for Agriculture, Environment and Development
dc.relationCHANGE - Global Change and Sustainability Institute
dc.relation.ispartofFoods
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectLignans
dc.subjectDietary polyphenols
dc.subjectPhytochemicals
dc.subjectSecoisolariciresinol diglucoside
dc.subjectMolecular mechanism
dc.titleMolecular mechanisms of lignans in lowering blood pressure and anti-obesity effects: a revieweng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMediterranean Institute for Agriculture, Environment and Development
oaire.awardTitleCHANGE - Global Change and Sustainability Institute
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05183%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0121%2F2020/PT
oaire.citation.issue2
oaire.citation.startPage336
oaire.citation.titleFoods
oaire.citation.volume15
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGonçalves
person.familyNameRomano
person.givenNameSandra
person.givenNameAnabela
person.identifier.ciencia-id9F19-E3AE-2C59
person.identifier.ciencia-id8A18-7E9A-3B0E
person.identifier.orcid0000-0002-3038-4434
person.identifier.orcid0000-0002-7204-7428
person.identifier.ridM-6988-2017
person.identifier.scopus-author-id8583003200
person.identifier.scopus-author-id56249997600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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relation.isAuthorOfPublication.latestForDiscoverya8b335b2-45cc-4578-89b0-153273014280
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