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Sapwood of carob tree (Ceratonia siliqua L.) as a potential source of bioactive compounds

2013Journal article Open Access
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dc.contributor.authorCustódio, Luísa
dc.contributor.authorEscapa, Ana Luísa
dc.contributor.authorPatarra, João
dc.contributor.authorAligué, Rosa
dc.contributor.authorAlberício, Fernando
dc.contributor.authorNeng, Nuno Rosa
dc.contributor.authorNogueira, José Manuel F.
dc.contributor.authorRomano, Anabela
dc.date.accessioned2015-06-18T10:12:41Z
dc.date.available2015-06-18T10:12:41Z
dc.date.issued2013
dc.description.abstractMethanol (ME) and hot water extracts (WE) of carob tree sapwood (Ceratonia siliqua L.) exhibited high antioxidant activity and were rich in phenolic compounds, with the main compounds identified by HPLC/DAD as gentisic acid and (-)-epicatechin. The ME displayed a high in vitro antitumor activity against human tumoural cell lines and reduced intracellular ROS production by HeLa cells after treatment with H2O2. (-)-Epicatechin was shown to contribute to the cytotoxic activity of the ME. This is the first report on the biological activity of carob tree sapwood.
dc.identifier.issn1307-6167
dc.identifier.otherAUT: ARO01015;
dc.identifier.urihttp://hdl.handle.net/10400.1/6456
dc.language.isoeng
dc.peerreviewedyes
dc.publisherACG Publications
dc.relation.isbasedonP-005-3A3
dc.subjectAntioxidant activity
dc.subjectCytotoxic
dc.subjectGentisic acid
dc.subjectPhenolic compounds
dc.subjectROS
dc.titleSapwood of carob tree (Ceratonia siliqua L.) as a potential source of bioactive compounds
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage229
oaire.citation.issue3
oaire.citation.startPage225
oaire.citation.titleRecords of Natural Products
oaire.citation.volume7
person.familyNameCustódio
person.familyNameRomano
person.givenNameLuísa
person.givenNameAnabela
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.ciencia-id8A18-7E9A-3B0E
person.identifier.orcid0000-0003-4338-7703
person.identifier.orcid0000-0002-7204-7428
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id15831018900
person.identifier.scopus-author-id56249997600
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
relation.isAuthorOfPublicatione3343b60-17d3-4f5e-a2bf-06f26da69206
relation.isAuthorOfPublication.latestForDiscoverye3343b60-17d3-4f5e-a2bf-06f26da69206

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