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Microalgae as potential sources of bioactive compounds for functional foods and pharmaceuticals

2022-06-09Journal article Open access
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dc.contributor.authorSilva, Mélanie
dc.contributor.authorKamberovic, Farah
dc.contributor.authorUota, Sisay Tesema
dc.contributor.authorKovan, Ismael-Mohammed
dc.contributor.authorViegas, Carla
dc.contributor.authorSimes, D
dc.contributor.authorGangadhar, Katkam N.
dc.contributor.authorJoão, Varela
dc.contributor.authorBarreira, Luísa
dc.date.accessioned2022-07-14T09:44:21Z
dc.date.available2022-07-14T09:44:21Z
dc.date.issued2022-06-09
dc.date.updated2022-06-23T12:11:47Z
dc.description.abstractMicroalgae are an untapped source of bioactive compounds with various biotechnological applications. Several species are industrially produced and commercialized for the feed or cosmetic industries, however, other applications in the functional food and pharmaceutical markets can be foreseen. In this study, nine industrial/commercial species were evaluated for in vitro antioxidant, calcium-chelating, anti-tumoral, and anti-inflammatory activities. The most promising extracts were fractionated yielding several promising fractions namely, of Tetraselmis striata CTP4 with anti-inflammatory activity (99.0 ± 0.8% reduction in TNF-α production in LPS stimulated human macrophages at 50 µg/mL), of Phaeodactylum Tricornutum with cytotoxicity towards cancerous cell lines (IC50 = 22.3 ± 1.8 µg/mL and 27.5 ± 1.6 µg/mL for THP-1 and HepG2, respectively) and of Porphyridium sp. and Skeletonema sp. with good chelating activity for iron, copper and calcium (IC50 = 0.047, 0.272, 0.0663 mg/mL and IC50 = 0.055, 0.240, 0.0850 mg/mL, respectively). These fractions were chemically characterized by GC–MS after derivatization and in all, fatty acids at various degrees of unsaturation were the most abundant compounds. Some of the species under study proved to be potentially valuable sources of antioxidant, metal chelators, anti-tumoral and anti-inflammatory compounds with possible application in the functional food and pharmaceutical industries.pt_PT
dc.description.sponsorshipEC/H2020/101000501/EU; AAC No. 41/ALG/2020—Project No. 072583
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationApplied Sciences 12 (12): 5877 (2022)pt_PT
dc.identifier.doi10.3390/app12125877pt_PT
dc.identifier.eissn2076-3417
dc.identifier.urihttp://hdl.handle.net/10400.1/17990
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnti-inflammatory activitypt_PT
dc.subjectAnti-tumoral activitypt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectBioactive compoundspt_PT
dc.subjectNeuroprotective compoundspt_PT
dc.subjectHealth benefitspt_PT
dc.titleMicroalgae as potential sources of bioactive compounds for functional foods and pharmaceuticalspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.citation.issue2pt_PT
oaire.citation.startPage5877pt_PT
oaire.citation.titleApplied Sciencespt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSilva
person.familyNameKamberovic
person.familyNameUota
person.familyNameViegas
person.familyNameSimes
person.familyNameVarela
person.familyNameBarreira
person.givenNameMélanie
person.givenNameFarah
person.givenNameSisay Tesema
person.givenNameCarla
person.givenNameDina
person.givenNameJoão
person.givenNameLuísa
person.identifier.ciencia-idC414-F596-EEC6
person.identifier.ciencia-id6D1A-17E5-1400
person.identifier.orcid0000-0002-0460-646X
person.identifier.orcid0000-0001-8444-0342
person.identifier.orcid0000-0001-8957-2424
person.identifier.orcid0000-0002-5765-3665
person.identifier.orcid0000-0002-5145-4753
person.identifier.orcid0000-0003-3101-693X
person.identifier.orcid0000-0002-4077-855X
person.identifier.ridN-6695-2014
person.identifier.ridN-2789-2014
person.identifier.ridM-4223-2013
person.identifier.scopus-author-id8656310300
person.identifier.scopus-author-id7201884723
person.identifier.scopus-author-id55741416000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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