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Dietary 1.3-1.6 yeast β-glucans enhance immune response and disease resilience in European seabass challenged with Tenacibaculum maritimum

2026-04-20Artigo científico Acesso aberto
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datacite.subject.sdg14:Proteger a Vida Marinha
datacite.subject.sdg02:Erradicar a Fome
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorOrelhas Cabano, Miguel
dc.contributor.authorRichard, Nadège
dc.contributor.authorSchulthess, Julie
dc.contributor.authorPinto, Lourenço Ramos
dc.contributor.authorCunha, Francisco Pinto
dc.contributor.authorPeixoto, Maria João
dc.contributor.authorAragão, Cláudia
dc.contributor.authorCostas, Benjamin
dc.date.accessioned2026-06-24T08:31:44Z
dc.date.available2026-06-24T08:31:44Z
dc.date.issued2026-04-20
dc.description.abstractIntroduction: Nutritional strategies have emerged as promising tools to modulate immune responses in marine fish, particularly at mucosal surfaces involved in host-pathogen interactions. Dietary immunomodulators such as yeast-derived bglucans (BG) have gained attention for their capacity to enhance innate immune defenses, however their role in coordinating these mechanisms during bacterial infections remains incompletely understood. Methods: This study evaluated the effects of two dietary inclusion levels (0.06 and 0.12%) of purified yeast b-1,3/1,6-glucans on the immune responses of European seabass (Dicentrarchus labrax) following a bath challenge with Tenacibaculum maritimum specifically. After four weeks of feeding with experimental diets, fish were exposed to a sub-lethal infection, and immune parameters were accessed in the skin, intestinal mucosa and at systemic level. Results: Growth performance and feed efficiency were not affected by BG supplementation. At 24 h post-infection, fish fed with the 0.12% BG diet maintained circulating leukocyte counts and displayed increased plasma lysozyme activity, indicating enhanced early immune readiness. Moreover skin immune responses showed an early upregulation of pro-inflammatory and antimicrobial related genes, followed by increased expression of regulatory cytokines at 7 days post-infection, suggesting an efficient transition from immune activation to resolution. In contrast, intestinal immune responses remained largely unchanged, indicating a compartmentalized modulation focused on the primary site of infection. Conclusion: Overall, dietary BG supplementation exerted a dose dependent immunostimulatory effect in European seabass, with 0.12% BG eliciting the most significant chances in disease resilienceeng
dc.description.sponsorshipUID/04326/2025; UID/04423/2025; UID/PRR/04326/2025; UID/PRR/04423/2025
dc.identifier.doi10.3389/fimmu.2026.1798375
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/10400.1/29131
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media SA
dc.relationCentre for Marine and Environmental Research
dc.relation.ispartofFrontiers in Immunology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAquaculture
dc.subjectBacterial pathogen
dc.subjectDicentrarchus labrax
dc.subjectFeed additives
dc.subjectImmunization
dc.subjectImmunonutrition
dc.titleDietary 1.3-1.6 yeast β-glucans enhance immune response and disease resilience in European seabass challenged with Tenacibaculum maritimumeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberLA/P/0101/2020
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.citation.titleFrontiers in immonology
oaire.citation.volume17
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameOrelhas Cabano
person.familyNameAragão
person.givenNameMiguel
person.givenNameCláudia
person.identifierDXm3Kj0AAAAJ
person.identifier174173
person.identifier.ciencia-idD612-B91F-F943
person.identifier.ciencia-idD01E-0726-9F3E
person.identifier.orcid0000-0002-4909-6715
person.identifier.orcid0000-0002-9217-0183
person.identifier.ridK-2310-2012
person.identifier.scopus-author-id55903315700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication268955b1-80d8-4bad-97d4-1e9904e0a5fa
relation.isAuthorOfPublicationbc649967-3b39-41dc-8fab-b60c24e65286
relation.isAuthorOfPublication.latestForDiscovery268955b1-80d8-4bad-97d4-1e9904e0a5fa
relation.isProjectOfPublication794d4c77-c731-471e-bc96-5a41dcd3d872
relation.isProjectOfPublication.latestForDiscovery794d4c77-c731-471e-bc96-5a41dcd3d872

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