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An overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalation

2020Journal article Open access
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dc.contributor.authorMarante, Tânia
dc.contributor.authorViegas, Cláudia Sofia
dc.contributor.authorDuarte, Inês
dc.contributor.authorMacedo, Ana S.
dc.contributor.authorFonte, Pedro
dc.date.accessioned2020-12-17T10:32:44Z
dc.date.available2020-12-17T10:32:44Z
dc.date.issued2020
dc.description.abstractThe delivery of therapeutic proteins remains a challenge, despite recent technological advances. While the delivery of proteins to the lungs is the gold standard for topical and systemic therapy through the lungs, the issue still exists. While pulmonary delivery is highly attractive due to its non-invasive nature, large surface area, possibility of topical and systemic administration, and rapid absorption circumventing the first-pass effect, the absorption of therapeutic proteins is still ineffective, largely due to the immunological and physicochemical barriers of the lungs. Most studies using spray-drying for the nanoencapsulation of drugs focus on the delivery of conventional drugs, which are less susceptible to bioactivity loss, compared to proteins. Herein, the development of polymeric nanoparticles by spray-drying for the delivery of therapeutic proteins is reviewed with an emphasis on its advantages and challenges, and the techniques to evaluate their in vitro and in vivo performance. The protein stability within the carrier and the features of the carrier are properly addressed.pt_PT
dc.description.sponsorshipFCT: UIDB/50006/2020, UIDB/04326/2020, and UIDB/04565/2020.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/pharmaceutics12111032pt_PT
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/10400.1/14918
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectProtein deliverypt_PT
dc.subjectPolymeric nanoparticlept_PT
dc.subjectParticle depositionpt_PT
dc.subjectBronchipt_PT
dc.subjectLungpt_PT
dc.subjectPulmonary deliverypt_PT
dc.subjectInhalationpt_PT
dc.subjectAtomizationpt_PT
dc.subjectSpray-dryingpt_PT
dc.subjectDry powderpt_PT
dc.titleAn overview on spray-drying of protein-loaded polymeric nanoparticles for dry powder inhalationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11pt_PT
oaire.citation.startPage1032pt_PT
oaire.citation.titlePharmaceuticspt_PT
oaire.citation.volume12pt_PT
person.familyNameMarante
person.familyNameMestre Viegas
person.familyNameFonte
person.givenNameTânia
person.givenNameCláudia Sofia
person.givenNamePedro
person.identifier.ciencia-id1D15-BB12-D878
person.identifier.ciencia-idBC13-CBFD-ECA6
person.identifier.ciencia-id2410-123D-3385
person.identifier.orcid0000-0003-0000-9104
person.identifier.orcid0000-0001-6668-2778
person.identifier.orcid0000-0002-1115-9282
person.identifier.ridK-3215-2013
person.identifier.scopus-author-id55146900200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione50b912c-6736-4334-8731-e141d29356fd
relation.isAuthorOfPublication0bc1b0e2-46bd-4fb1-a3aa-f27ca4a55695
relation.isAuthorOfPublicationa5a5c2b2-9112-4bf4-8618-8c2051bbc116
relation.isAuthorOfPublication.latestForDiscovery0bc1b0e2-46bd-4fb1-a3aa-f27ca4a55695

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