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Zebrafish as a model to study craniofacial phenotypes related to human MEF2Cmutations

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dc.contributor.authorAdrião, Andreia Lúcia Gonçalves
dc.contributor.authorConceição, N.
dc.contributor.authorGavaia, Paulo J.
dc.contributor.authorCancela, Leonor
dc.date.accessioned2014-06-05T13:37:10Z
dc.date.available2014-06-05T13:37:10Z
dc.date.issued2013
dc.date.updated2014-05-30T09:58:09Z
dc.description.abstractBackground: MEF2C is a transcription factor with important roles in differentiation and developmental processes, in particular in endochondral bone development. An association between human MEF2C gene mutations and particular phenotypes affecting craniofacial formation has been shown. Recent studies have shown that the zebrafish palate is under a genetic control similar to that controlling amniotic palatal skeleton, demonstrating the utility of this organism to study craniofacial development. Zebrafish has two mef2c genes and different lines of mutants are available. Therefore we have used zebrafish in an attempt to correlate specific MEF2C mutations with the abnormal human craniofacial phenotypes.por
dc.identifier.citationAdriao, A.; Conceicao, N.; Gavaia, P. J.; Cancela, M. L. Zebrafish as a model to study craniofacial phenotypes related to human MEF2Cmutations, European Journal of Clinical Investigation, 43, Set. 2013, 102-102, 2013.por
dc.identifier.issn0014-2972
dc.identifier.otherAUT: LCA00739;
dc.identifier.urihttp://hdl.handle.net/10400.1/4199
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.titleZebrafish as a model to study craniofacial phenotypes related to human MEF2Cmutationspor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage102por
oaire.citation.issueSet. 2013por
oaire.citation.startPage102por
oaire.citation.titleEuropean Journal of Clinical Investigationpor
oaire.citation.volume43por
person.familyNameAdrião
person.familyNameGavaia
person.familyNameCancela
person.givenNameAndreia Lúcia Gonçalves
person.givenNamePaulo
person.givenNameM. Leonor
person.identifier.ciencia-idB619-FC16-D007
person.identifier.orcid0000-0001-6018-9114
person.identifier.orcid0000-0002-9582-1957
person.identifier.orcid0000-0003-3114-6662
person.identifier.ridA-6470-2011
person.identifier.scopus-author-id16070252800
person.identifier.scopus-author-id6507104377
rcaap.rightsrestrictedAccesspor
rcaap.typeconferenceObjectpor
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relation.isAuthorOfPublicationb9bbfe32-3dfe-4131-ad14-a4394008447f
relation.isAuthorOfPublication.latestForDiscoveryb9bbfe32-3dfe-4131-ad14-a4394008447f

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