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Extracellular bioelectrical lexicon: detecting rhythmic patterns within dermal fibroblast populations

2025-08-14Journal article Open access
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dc.contributor.authorFélix, Rute
dc.contributor.authorMedeiros, Maria do Carmo
dc.contributor.authorElamine, Youssef
dc.contributor.authorPower, Deborah Mary
dc.contributor.authorGomes, Henrique Leonel
dc.date.accessioned2025-09-22T12:55:12Z
dc.date.available2025-09-22T12:55:12Z
dc.date.issued2025-08-14
dc.description.abstractThis study uses a bioelectronic-based method to establish how non-electrogenic cells, like dermal fibroblast, employ bioelectrical signals to convey information. Electrophysiology using large-area Multielectrode Arrays (MEAs) devices revealed how populations of non-electrogenic cells in vitro generate patterns of bioelectrical signals. The period of the bioelectrical patterns depends on cell population activity. In a fully formed, healthy monolayer, bioelectrical activity is minimal. But during the formation of a monolayer, signals appear randomly, with a dominant period of 4.2 min. Occasionally, quasi-periodic bursts occur with a period between 1.6 and 2 min. When a mechanical wound is inflicted and during subsequent monolayer repair, quasi-periodic signal bursts occur, with an average period ranging from 60 to 110 min. The study uncovers a short-range non humoral communication system and a lexicon of bioelectrical signals linked to cell states.eng
dc.description.sponsorshipThe project 2022.06979; UIDB/EEA/50008/2020; EMBRC.PT ALG-01-0145-FEDER-022121; DL57/2016/CP1361/CT0020
dc.identifier.doi10.1038/s41598-025-15071-z
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.1/27721
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relation.ispartofScientific Reports
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectElectrophysiology
dc.subjectNon-excitable cells
dc.subjectExtra-cellular electrodes
dc.subjectBioelectricity
dc.subjectFibroblasts
dc.titleExtracellular bioelectrical lexicon: detecting rhythmic patterns within dermal fibroblast populationseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.citation.issue1
oaire.citation.startPage29857
oaire.citation.titleNature
oaire.citation.volume15
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFélix
person.familyNameMedeiros
person.familyNamePower
person.familyNameGomes
person.givenNameRute
person.givenNameMaria do Carmo
person.givenNameDeborah Mary
person.givenNameHenrique Leonel
person.identifier.ciencia-idFB1A-1325-8E25
person.identifier.ciencia-id261D-647A-77E8
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-4144-3452
person.identifier.orcid0000-0003-2277-2848
person.identifier.orcid0000-0003-1366-0246
person.identifier.orcid0000-0003-3664-4740
person.identifier.ridM-6164-2013
person.identifier.ridL-1403-2016
person.identifier.scopus-author-id56006773000
person.identifier.scopus-author-id8411595900
person.identifier.scopus-author-id7101806760
person.identifier.scopus-author-id7005305880
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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