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Sulphated locust bean gum-coated lipid nanocapsules as potential lung delivery carriers

2020-04Conference object Open access
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dc.contributor.authorPontes, Jorge Filipe
dc.contributor.authorBraz, L.
dc.contributor.authorGuerreiro, Filipa
dc.contributor.authorRosa Da Costa, Ana
dc.contributor.authorAlmouazen, Eyad
dc.contributor.authorLollo, Giovanna
dc.contributor.authorGrenha, Ana
dc.date.accessioned2021-06-24T11:35:46Z
dc.date.available2021-06-24T11:35:46Z
dc.date.issued2020-04
dc.description.abstractDrugs pertaining to Biopharmaceutics Classification System (BCS) classes II and IV have limitations in their delivery, including in the lung. Therefore, drug delivery carriers have been proposed to improve the therapeutic effectiveness of such drugs. This work proposes lipid nanocapsules (LNC) as a potential platform for lung drug delivery. Locust bean gum (LBG), which is a galactomannan, was used as polymeric shell, protecting the oily core of the nanocapsules and providing their surface with hydrophilic character. Due to the neutral character of LBG, in order to enable nanocapsule formation, a sulphate derivative (LBGS) was prepared, which was confirmed by Fourier-transformed infrared (FTIR) spectroscopy. The electrostatic interaction between the negatively charged sulphate groups of LBGS and the positively charged groups of the used cationic lipid (1,2-dioleoyloxy-3- trimethylammoniumpropanchloride, DOTAP), allowed the formation of monodisperse nanocapsules, with sizes around 200 nm and strongly negative zeta potentials, between -70 and -85 mV. Envisaging potential lung drug delivery, the LBGS-coated LNC were co-formulated with mannitol using spray-drying, producing microencapsulated nanocapsules. Feret’s diameter was determined to be 2.6 ± 1.8 µm and 3.1 ± 1.9 µm for Man (control) and Man/LNC microparticles, respectively. Further studies are underway in order to optimise both the nanoplatform and the dry powder formulation.
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.issn1941-2711
dc.identifier.urihttp://hdl.handle.net/10400.1/16531
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMary Ann Liebert
dc.subject.otherRespiratory System
dc.titleSulphated locust bean gum-coated lipid nanocapsules as potential lung delivery carriers
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPageA15
oaire.citation.issue2
oaire.citation.titleJournal of Aerosol Medicine and Pulmonary Drug Delivery
oaire.citation.volume33
person.familyNamePontes
person.familyNameBraz
person.familyNameGuerreiro
person.familyNameRosa da Costa
person.familyNameGrenha
person.givenNameJorge Filipe
person.givenNameLuis
person.givenNameFilipa
person.givenNameAna M
person.givenNameAna
person.identifier305029
person.identifier.ciencia-idCB16-5CBD-8B89
person.identifier.ciencia-idBA15-0A43-361F
person.identifier.ciencia-idBF1D-7EFA-19BC
person.identifier.ciencia-idA418-A85E-5DB1
person.identifier.ciencia-id091C-0D58-7225
person.identifier.orcid0000-0002-6447-0242
person.identifier.orcid0000-0002-1500-1976
person.identifier.orcid0000-0001-6224-1553
person.identifier.orcid0000-0003-0225-9537
person.identifier.orcid0000-0002-2136-1396
person.identifier.ridE-1901-2012
person.identifier.ridE-2165-2012
person.identifier.ridH-1392-2017
person.identifier.scopus-author-id57195033461
person.identifier.scopus-author-id55996112700
person.identifier.scopus-author-id53986075100
person.identifier.scopus-author-id8607930100
rcaap.rightsrestrictedAccess
rcaap.typeconferenceObject
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