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Differentiation of vascular characteristics using contrast-enhanced ultrasound imaging

2019Journal article Open access
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dc.contributor.authorButler, Mairead
dc.contributor.authorPerperidis, Antonios
dc.contributor.authorZahra, Jean-Luc Matteo
dc.contributor.authorSilva, Nadia
dc.contributor.authorAverkiou, Michalakis
dc.contributor.authorDuncan, W. Colin
dc.contributor.authorMcNeilly, Alan
dc.contributor.authorSboros, Vassilis
dc.date.accessioned2020-08-04T14:02:34Z
dc.date.available2020-08-04T14:02:34Z
dc.date.issued2019
dc.description.abstractUltrasound contrast imaging has been used to assess tumour growth and regression by assessing the flow through the macro- and micro-vasculature. Our aim was to differentiate the blood kinetics of vessels such as veins, arteries and microvasculature within the limits of the spatial resolution of contrast-enhanced ultrasound imaging. The highly vascularised ovine ovary was used as a biological model. Perfusion of the ovary with SonoVue was recorded with a Philips iU22 scanner in contrast imaging mode. One ewe was treated with prostaglandin to induce vascular regression. Time-intensity curves (TIC) for different regions of interest were obtained, a lognormal model was fitted and flow parameters calculated. Parametric maps of the whole imaging plane were generated for 2 × 2 pixel regions of interest. Further analysis of TICs from selected locations helped specify parameters associated with differentiation into four categories of vessels (arteries, veins, medium-sized vessels and micro-vessels). Time-dependent parameters were associated with large veins, whereas intensity-dependent parameters were associated with large arteries. Further development may enable automation of the technique as an efficient way of monitoring vessel distributions in a clinical setting using currently available scanners.pt_PT
dc.description.sponsorshipAgência financiadora Medical Research Council UK (MRC) 30800896 Science & Technology Facilities Council (STFC) ST/M007804/1 British Heart Foundation PG/10/021/28254 Life Sciences Discovery Fund 3292512 United States Department of Defense CA160415/PRCRPpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ultrasmedbio.2019.05.015pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.1/14598
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectContrast mediapt_PT
dc.subjectFemalept_PT
dc.subjectIn vitro techniquespt_PT
dc.subjectOvarypt_PT
dc.subjectPhospholipidspt_PT
dc.subjectReproducibility of resultspt_PT
dc.subjectSheeppt_PT
dc.subjectSulfur Hexafluoridept_PT
dc.subjectUltrasonographypt_PT
dc.subjectDopplerpt_PT
dc.titleDifferentiation of vascular characteristics using contrast-enhanced ultrasound imagingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2455pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage2444pt_PT
oaire.citation.titleUltrasound in Medicine and Biologypt_PT
oaire.citation.volume45pt_PT
person.familyNameSilva
person.givenNameNádia
person.identifier.ciencia-id5D1F-6F3A-A1C2
person.identifier.orcid0000-0001-9881-4421
person.identifier.scopus-author-id10244362100
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa467188c-1363-4f77-a9a9-8297de10a01a
relation.isAuthorOfPublication.latestForDiscoverya467188c-1363-4f77-a9a9-8297de10a01a

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