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Pluronic® triblock copolymer-based nanoformulations for cancer therapy: A 10-year overview

2023Journal article Restricted access
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dc.contributor.authorde Castro, Karine Cappuccio
dc.contributor.authorCoco, Julia Cedran
dc.contributor.authordos Santos, Érica Mendes
dc.contributor.authorAtaide, Janaína Artem
dc.contributor.authorMartinez, Renata Miliani
dc.contributor.authordo Nascimento, Mônica Helena Monteiro
dc.contributor.authorPrata, João
dc.contributor.authorFonte, Pedro
dc.contributor.authorSeverino, Patrícia
dc.contributor.authorMazzola, Priscila Gava
dc.contributor.authorBaby, André Rolim
dc.contributor.authorSouto, Eliana Barbosa
dc.contributor.authorde Araujo, Daniele Ribeiro
dc.contributor.authorLopes, André Moreni
dc.date.accessioned2023-03-03T21:06:17Z
dc.date.available2023-03-03T21:06:17Z
dc.date.issued2023
dc.description.abstractThis paper provides a review of the literature on the use of Pluronic (R) triblock copolymers for drug encapsulation over the last 10 years. A special focus is given to the progress of drug delivery systems (e.g., micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, and polymersomes and niosomes); the beneficial aspects of Pluronic (R) triblock copolymers as biological response modifiers and as pharmaceutical additives, adjuvants, and stabilizers, are also discussed. The advantages and limitations encountered in developing site-specific targeting approaches based on Pluronic-based nanostructures in cancer treatment are highlighted, in addition to inno-vative examples for improving tumor cytotoxicity while reducing side effects.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.jconrel.2022.12.017pt_PT
dc.identifier.issn0168-3659
dc.identifier.urihttp://hdl.handle.net/10400.1/19196
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationLA/P/0101/2020pt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationInstitute for Bioengineering and Biosciences
dc.relationInstitute for Bioengineering and Biosciences
dc.subjectPluronic?pt_PT
dc.subjectAmphiphilic copolymerspt_PT
dc.subjectSelf-assemblypt_PT
dc.subjectDrug delivery systems (DDS)pt_PT
dc.subjectNanostructures (NSs)pt_PT
dc.subjectCancer therapypt_PT
dc.titlePluronic® triblock copolymer-based nanoformulations for cancer therapy: A 10-year overviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04565%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04565%2F2020/PT
oaire.citation.endPage822pt_PT
oaire.citation.startPage802pt_PT
oaire.citation.titleJournal of Controlled Releasept_PT
oaire.citation.volume353pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFonte
person.givenNamePedro
person.identifier.ciencia-id2410-123D-3385
person.identifier.orcid0000-0002-1115-9282
person.identifier.ridK-3215-2013
person.identifier.scopus-author-id55146900200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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