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Effect of a polymetallic mixture on metal accumulation and metallothionein response in the clam Ruditapes decussatus

2010Journal article Restricted access
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dc.contributor.authorSerafim, Angela
dc.contributor.authorBebianno, Maria João
dc.date.accessioned2020-04-30T10:49:13Z
dc.date.available2020-04-30T10:49:13Z
dc.date.issued2010
dc.description.abstractThe toxic effects of metals are related to changes in natural physiological and biochemical processes in organisms, which are not easily detected. Marine invertebrates developed strategies to survive in the presence of toxic metal levels, by the removal of these compounds from the soluble fraction of the cell through different processes, including the synthesis of metallothionein (MT). To better understand the effect of Cd, Cu and Zn in MT response it is important to consider that in their natural environment these metals are normally mixed. The exposure to a metal mixture result in toxicological interactions that produce different biological responses when compared to the effects of a single metal exposure. The aim of this study was to assess metal accumulation and MT response in different tissues of the clam Ruditapes decussatus exposed to a mixture of sublethal Cd, Cu and Zn concentrations. Kinetic models were applied to determine metal uptake and loss to better predict and understand the detoxification mechanisms in this species. The kinetic model showed that the effect of this polymetallic exposure compared to a single exposure to these metals caused different metal uptake and loss rates in several tissues. Moreover, the exposure of R. decussatus to a polymetallic mixture caused an increase in MT induction compared to a single metal exposure. This is probably related to the interaction between the different metals and their different affinity to this protein. Metal interactions within aquatic organisms are very important in MT synthesis and the effect of polymetallic mixtures in the environment must be taken into account in field studies.pt_PT
dc.description.sponsorshipFCT PhD Grant (CIÊNCIA/BD/2541/93)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1016/j.aquatox.2010.05.016pt_PT
dc.identifier.issn0166-445X
dc.identifier.urihttp://hdl.handle.net/10400.1/13815
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0166445X10002092?via%3Dihubpt_PT
dc.subjectAnimalspt_PT
dc.subjectBivalviapt_PT
dc.subjectCadmiumpt_PT
dc.subjectComplex mixturespt_PT
dc.subjectCopperpt_PT
dc.subjectDose-response relationshippt_PT
dc.subjectKineticspt_PT
dc.subjectMetallothioneinpt_PT
dc.subjectModelspt_PT
dc.subjectZincpt_PT
dc.subjectDrugpt_PT
dc.subjectPolymetallic exposurept_PT
dc.subjectBioaccumulationpt_PT
dc.subjectRuditapes decussatuspt_PT
dc.titleEffect of a polymetallic mixture on metal accumulation and metallothionein response in the clam Ruditapes decussatuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage378pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage370pt_PT
oaire.citation.titleAquatic Toxicologypt_PT
oaire.citation.volume99pt_PT
person.familyNamePereira Serafim
person.familyNameBebianno
person.givenNameMaria Angela
person.givenNameMaria
person.identifier.ciencia-id9C18-090A-5E3D
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0002-1165-0645
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0e42fc03-7052-438d-952b-b3caa5bdc36a
relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery0e42fc03-7052-438d-952b-b3caa5bdc36a

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