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Metallothionein, zinc, and mercury levels in tissues of young rats exposed to zinc and subsequently to mercury

2007Journal article Restricted access
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dc.contributor.authorPeixoto, N. C.
dc.contributor.authorSerafim, M. A.
dc.contributor.authorFlores, E.M.M.
dc.contributor.authorBebianno, Maria João
dc.contributor.authorPereira, M. E.
dc.date.accessioned2020-05-07T14:18:59Z
dc.date.available2020-05-07T14:18:59Z
dc.date.issued2007
dc.description.abstractSeveral studies have described mercury toxicity and the role of metallothioneins (MT) in the detoxification and regulation of metal homeostasis. However, little data exist on this topic during the specific post-natal developmental phase in young mammals. This developmental phase is particularly important since young animals are more sensitive to toxicants than adults. The objective of this work was to investigate whether MT participates in the mechanism of protection conferred by zinc pre-treatment on the toxic effects induced by mercury in neonate rats. Pups were exposed to ZnCl(2) (5 doses of 27 mg/kg/day, s.c.) and subsequently to HgCl(2) (5 doses of 5 mg/kg/day, s.c.); metal (Zn and Hg) and MT contents were analyzed in the liver, kidney, and blood. MT was induced in the liver and kidney of pups of both Zn-sal and Zn-Hg groups, although the greatest increase was in neonates exposed to Zn only. A direct relationship exists between MT and metals for both hepatic and renal tissues, which indicates that the increase in metal levels occurs in parallel to the increase in MT content. Although the heat-treated cytosolic fraction is rich in MT and metals, higher Zn and Hg contents were detected in the insoluble fraction of all tissues. These results suggest that MT is, at least in part, responsible for preventing Hg accumulation in the liver and blood and decreasing renal toxicity.pt_PT
dc.description.sponsorshipN. C. P. was a recipient of fellowships from CAPES (PDEE)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.lfs.2007.08.038pt_PT
dc.identifier.issn0024-3205
dc.identifier.urihttp://hdl.handle.net/10400.1/13854
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectAnimalspt_PT
dc.subjectChloridespt_PT
dc.subjectFemalept_PT
dc.subjectKidneypt_PT
dc.subjectLiverpt_PT
dc.subjectMalept_PT
dc.subjectMercuric chloridept_PT
dc.subjectMetallothioneinpt_PT
dc.subjectRatspt_PT
dc.subjectRatspt_PT
dc.subjectZinc compoundspt_PT
dc.subjectMercury poisoningpt_PT
dc.subjectWistarpt_PT
dc.subjectNervous systempt_PT
dc.subjectNewbornpt_PT
dc.titleMetallothionein, zinc, and mercury levels in tissues of young rats exposed to zinc and subsequently to mercurypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1271pt_PT
oaire.citation.issue16pt_PT
oaire.citation.startPage1264pt_PT
oaire.citation.titleLife Sciencespt_PT
oaire.citation.volume81pt_PT
person.familyNameBebianno
person.givenNameMaria
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32

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