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Dopamine beta-hydroxylase and its role in regulating the growth and larval metamorphosis in Sinonovacula constricta

dc.contributor.authorLi, Zhi
dc.contributor.authorNiu, Donghong
dc.contributor.authorPeng, Maoxiao
dc.contributor.authorXiong, Ya
dc.contributor.authorJi, Jie
dc.contributor.authorDong, Zhiguo
dc.contributor.authorLi, Jiale
dc.date.accessioned2021-06-24T11:35:37Z
dc.date.available2021-06-24T11:35:37Z
dc.date.issued2020-05
dc.description.abstractDopamine beta-hydroxylase (D beta H) plays a key role in the synthesis of catecholamines (CAs) in the neuroendocrine regulatory network. The D beta H gene was identified from the razor clam Sinonovacula constricta and referred to as ScD beta H. The ScD beta H gene is a copper type II ascorbate-dependent monooxygenase with a DOMON domain and two Cu2_monooxygen domains. ScD beta H transcript expression was abundant in liver and hemolymph. During early development, ScD beta H expression significantly increased at the umbo larval stage. Furthermore, the inhibitors and siRNA of D beta H were screened. After challenge with D beta H inhibitor, the larval metamorphosis and survival rates, and juvenile growth were obviously decreased. Under the siRNA stress, the larval metamorphosis and survival rates were also significantly decreased. Therefore, ScD beta H may play an important regulating role in larval metamorphosis and juvenile growth.
dc.description.sponsorshipNational Key R&D Program of China [2019YFD0900400]
dc.description.sponsorshipNational Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31472278]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.gene.2020.144418
dc.identifier.issn0378-1119
dc.identifier.urihttp://hdl.handle.net/10400.1/16492
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.subjectSinonovacula constricta
dc.subjectDopamine beta-hydroxylase
dc.subjectLarval metamorphosis
dc.subjectGrowth
dc.subjectInhibitor
dc.subjectSIRNA
dc.subject.otherGenetics & Heredity
dc.titleDopamine beta-hydroxylase and its role in regulating the growth and larval metamorphosis in Sinonovacula constricta
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage144418
oaire.citation.titleGene
oaire.citation.volume737
person.familyNamePeng
person.givenNameMaoxiao
person.identifier.ciencia-id0A1D-96B9-27EB
person.identifier.orcid0000-0002-4855-1202
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication43d269d9-e043-4d27-b3ee-5f1f657dcd37
relation.isAuthorOfPublication.latestForDiscovery43d269d9-e043-4d27-b3ee-5f1f657dcd37

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