Publication
Dopamine beta-hydroxylase and its role in regulating the growth and larval metamorphosis in Sinonovacula constricta
dc.contributor.author | Li, Zhi | |
dc.contributor.author | Niu, Donghong | |
dc.contributor.author | Peng, Maoxiao | |
dc.contributor.author | Xiong, Ya | |
dc.contributor.author | Ji, Jie | |
dc.contributor.author | Dong, Zhiguo | |
dc.contributor.author | Li, Jiale | |
dc.date.accessioned | 2021-06-24T11:35:37Z | |
dc.date.available | 2021-06-24T11:35:37Z | |
dc.date.issued | 2020-05 | |
dc.description.abstract | Dopamine beta-hydroxylase (D beta H) plays a key role in the synthesis of catecholamines (CAs) in the neuroendocrine regulatory network. The D beta H gene was identified from the razor clam Sinonovacula constricta and referred to as ScD beta H. The ScD beta H gene is a copper type II ascorbate-dependent monooxygenase with a DOMON domain and two Cu2_monooxygen domains. ScD beta H transcript expression was abundant in liver and hemolymph. During early development, ScD beta H expression significantly increased at the umbo larval stage. Furthermore, the inhibitors and siRNA of D beta H were screened. After challenge with D beta H inhibitor, the larval metamorphosis and survival rates, and juvenile growth were obviously decreased. Under the siRNA stress, the larval metamorphosis and survival rates were also significantly decreased. Therefore, ScD beta H may play an important regulating role in larval metamorphosis and juvenile growth. | |
dc.description.sponsorship | National Key R&D Program of China [2019YFD0900400] | |
dc.description.sponsorship | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31472278] | |
dc.description.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.doi | 10.1016/j.gene.2020.144418 | |
dc.identifier.issn | 0378-1119 | |
dc.identifier.uri | http://hdl.handle.net/10400.1/16492 | |
dc.language.iso | eng | |
dc.peerreviewed | yes | |
dc.publisher | Elsevier | |
dc.subject | Sinonovacula constricta | |
dc.subject | Dopamine beta-hydroxylase | |
dc.subject | Larval metamorphosis | |
dc.subject | Growth | |
dc.subject | Inhibitor | |
dc.subject | SIRNA | |
dc.subject.other | Genetics & Heredity | |
dc.title | Dopamine beta-hydroxylase and its role in regulating the growth and larval metamorphosis in Sinonovacula constricta | |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.citation.startPage | 144418 | |
oaire.citation.title | Gene | |
oaire.citation.volume | 737 | |
person.familyName | Peng | |
person.givenName | Maoxiao | |
person.identifier.ciencia-id | 0A1D-96B9-27EB | |
person.identifier.orcid | 0000-0002-4855-1202 | |
rcaap.rights | restrictedAccess | |
rcaap.type | article | |
relation.isAuthorOfPublication | 43d269d9-e043-4d27-b3ee-5f1f657dcd37 | |
relation.isAuthorOfPublication.latestForDiscovery | 43d269d9-e043-4d27-b3ee-5f1f657dcd37 |
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