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Are physicochemical properties shaping the allergenic potency of plant allergens?

2022-02Journal article Restricted access
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dc.contributor.authorCosta, Joana
dc.contributor.authorBavaro, Simona Lucia
dc.contributor.authorBenede, Sara
dc.contributor.authorDiaz-Perales, Araceli
dc.contributor.authorBueno-Diaz, Cristina
dc.contributor.authorGelencser, Eva
dc.contributor.authorKlueber, Julia
dc.contributor.authorLarre, Colette
dc.contributor.authorLozano-Ojalvo, Daniel
dc.contributor.authorLupi, Roberta
dc.contributor.authorMafra, Isabel
dc.contributor.authorMazzucchelli, Gabriel
dc.contributor.authorMolina, Elena
dc.contributor.authorMonaci, Linda
dc.contributor.authorMartin-Pedraza, Laura
dc.contributor.authorPiras, Cristian
dc.contributor.authorRodrigues, Pedro M.
dc.contributor.authorRoncada, Paola
dc.contributor.authorSchrama, Denise
dc.contributor.authorCirkovic-Velickovic, Tanja
dc.contributor.authorVerhoeckx, Kitty
dc.contributor.authorVilla, Caterina
dc.contributor.authorKuehn, Annette
dc.contributor.authorHoffmann-Sommergruber, Karin
dc.contributor.authorHolzhauser, Thomas
dc.date.accessioned2021-06-24T11:35:18Z
dc.date.available2021-06-24T11:35:18Z
dc.date.issued2022-02
dc.description.abstractThis review searched for published evidence that could explain how different physicochemical properties impact on the allergenicity of food proteins and if their effects would follow specific patterns among distinct protein families. Owing to the amount and complexity of the collected information, this literature overview was divided in two articles, the current one dedicated to protein families of plant allergens and a second one focused on animal allergens. Our extensive analysis of the available literature revealed that physicochemical characteristics had consistent effects on protein allergenicity for allergens belonging to the same protein family. For example, protein aggregation contributes to increased allergenicity of 2S albumins, while for legumins and cereal prolamins, the same phenomenon leads to a reduction. Molecular stability, related to structural resistance to heat and proteolysis, was identified as the most common feature promoting plant protein allergenicity, although it fails to explain the potency of some unstable allergens (e.g. pollen-related food allergens). Furthermore, data on physicochemical characteristics translating into clinical effects are limited, mainly because most studies are focused on in vitro IgE binding. Clinical data assessing how these parameters affect the development and clinical manifestation of allergies is minimal, with only few reports evaluating the sensitising capacity of modified proteins (addressing different physicochemical properties) in murine allergy models. In vivo testing of modified pure proteins by SPT or DBPCFC is scarce. At this stage, a systematic approach to link the physicochemical properties with clinical plant allergenicity in real-life scenarios is still missing.
dc.description.sponsorshipEuropean Cooperation in Science and Technology (COST) Office
dc.description.sponsorshipCOSTEuropean Cooperation in Science and Technology (COST) [FA1402]
dc.description.sponsorshipFundacao para a Ciencia e TecnologiaPortuguese Foundation for Science and TechnologyEuropean Commission [UIDB 50006/2020]
dc.description.sponsorshipprojects AlleRiskAssess [PTDC/BAA-AGR/31720/2017, NORTE-01-0145-FEDER-00001]
dc.description.sponsorshipFCT - POPH-QREN [PD/BD/114576/2016]
dc.description.sponsorshipMinistry of Education, Science and Technological Development of the Republic of Serbia [OI172024]
dc.description.sponsorshipFCTPortuguese Foundation for Science and TechnologyEuropean Commission [UIDB/04326/2020, 16-02-01-FMP0014]
dc.description.sponsorshipFonds National de la Recherche (FNR)Luxembourg National Research Fund [PRIDE/11012546/NEXTIMMUNE]
dc.description.sponsorshipPersonalised Medicine Consortium (PMC), Luxembourg [PMC/2017/02]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1007/s12016-020-08810-9
dc.identifier.issn1080-0549
dc.identifier.urihttp://hdl.handle.net/10400.1/16400
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer.
dc.subjectPlant allergens
dc.subjectProtein families
dc.subjectAllergenicity
dc.subjectFood processing
dc.subjectMatrix effect
dc.subject.otherAllergy
dc.titleAre physicochemical properties shaping the allergenic potency of plant allergens?
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleClinical Reviews In Allergy & Immunology
person.familyNameSchrama
person.givenNameDenise
person.identifier159154
person.identifier.ciencia-id501C-AC69-68C0
person.identifier.orcid0000-0003-0274-5957
person.identifier.ridH-6511-2016
person.identifier.scopus-author-id55755583400
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication00f4fa6e-b467-4d5c-83f2-a454f7b4bc71
relation.isAuthorOfPublication.latestForDiscovery00f4fa6e-b467-4d5c-83f2-a454f7b4bc71

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