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A single-stranded DNA virus replicates in the mitochondria of a marine oomycete

2026Artigo científico Acesso aberto
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datacite.subject.sdg14:Proteger a Vida Marinha
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg13:Ação Climática
dc.contributor.authorSakuta, Kohei
dc.contributor.authorKrupovic, Mart
dc.contributor.authorHejna, Ondřej
dc.contributor.authorMaia, Cristiana
dc.contributor.authorJung, Marília Horta
dc.contributor.authorKomatsu, Ken
dc.contributor.authorMoriyama, Hiromitsu
dc.contributor.authorJung, Thomas
dc.contributor.authorBotella, Leticia
dc.date.accessioned2026-09-16T14:26:35Z
dc.date.available2026-09-16T14:26:35Z
dc.date.issued2026
dc.description.abstractA virus with a circular single-stranded DNA genome, HthCRESSV1, was discovered in an oomycete, Halophytophthora thermoambigua, isolated from brackish waters off the Algarve coast in southern Portugal. Phylogenetic analyses place this virus outside of all currently classified families within the phylum Cressdnaviricota, suggesting it represents a distinct lineage. Cellular fractionation, mitochondrial marker co-enrichment, and Southern blot analyses indicate that HthCRESSV1 is associated with mitochondria and replicates episomally. The virus is stably transmitted through zoospores and is associated with a reduced host mycelial growth. Homologous sequences corresponding to both the replication-associated protein and a membrane-associated hypothetical protein were identified in the mitochondrial genomes of several oomycete species, suggesting recurrent endogenization of HthCRESSV1-like viruses in oomycete mitochondria. Together, these findings expand the known diversity of oomycete-associated DNA viruses, identify mitochondria as an unexpected niche for DNA virus replication, and highlight marine environments as underexplored reservoirs of DNA viruses in stramenopiles.eng
dc.description.sponsorshipEC/HE/101087262/ERA
dc.identifier.doi10.1093/ve/veag047
dc.identifier.issn2057-1577
dc.identifier.urihttp://hdl.handle.net/10400.1/29449
dc.language.isoeng
dc.peerreviewedyes
dc.publisherOxford University Press (OUP)
dc.relation.ispartofVirus Evolution
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCressdnaviricota
dc.subjectHUH superfamily rolling-circle replication endonuclease
dc.subjectOomycota
dc.subjectMitochondrial integration
dc.subjectViral endogenization
dc.subjectChondriosomes
dc.subjectRespiration
dc.titleA single-stranded DNA virus replicates in the mitochondria of a marine oomyceteeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.titleVirus Evolution
oaire.citation.volume12
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMaia
person.givenNameCristiana
person.identifier.ciencia-idBC15-6F7F-F84A
person.identifier.orcid0000-0002-8654-2905
person.identifier.ridD-6946-2017
person.identifier.scopus-author-id56106673800
relation.isAuthorOfPublicatione2c8b094-8efd-417a-8e7a-2713665f70df
relation.isAuthorOfPublication.latestForDiscoverye2c8b094-8efd-417a-8e7a-2713665f70df

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