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Ethnomedicinal uses, phytochemistry and bioactivities of halophytes and salt-tolerant plants with potential against metabolic syndrome: a comprehensive review

2026-07-29Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg15:Proteger a Vida Terrestre
datacite.subject.sdg02:Erradicar a Fome
dc.contributor.authorRodrigues, Maria João
dc.contributor.authorGarcía-Caparrós, Pedro
dc.contributor.authorGuerreiro Pereira, Catarina Alexandra
dc.contributor.authorMagné, Christian
dc.contributor.authorHamed, Karim Ben
dc.contributor.authorMesquita, Mariana Laundry de
dc.contributor.authorCustódio, Luísa
dc.date.accessioned2026-09-22T15:23:51Z
dc.date.available2026-09-22T15:23:51Z
dc.date.issued2026-07-29
dc.description.abstractMetabolic syndrome (MetS) is a complex cluster of interconnected metabolic abnormalities, including central obesity, insulin resistance, dyslipidemia, hypertension, chronic inflammation, and impaired glucose metabolism, which collectively increase the risk of type 2 diabetes and cardiovascular diseases. Although current therapeutic strategies, including lifestyle interventions and pharmacological treatments, can be effective in managing specific MetS components, the multifactorial nature of this condition continues to encourage the search for complementary approaches and novel bioactive compounds. Salt-tolerant plants (STPs), particularly halophytes, survive under adverse saline and oxidative stress conditions through specialized physiological and biochemical adaptations, including the production of diverse secondary metabolites such as phenolic acids, flavonoids, sterols, terpenoids and polysaccharides. Several of these compounds have been associated with health-promoting properties, including antioxidant, anti-inflammatory, antidiabetic, antihypertensive, lipid-modulating and cardioprotective effects. This review provides an integrated and critical overview of the ethnomedicinal uses, phytochemistry and bioactivities of STPs with potential relevance to MetS and its associated conditions, namely chronic inflammation, diabetes, hypertension, cardiovascular disorders, dyslipidemia and obesity. The review first introduces the main features of MetS and the relevance of STPs as bioresources, followed by a synthesis of ethnomedicinal uses related to MetS-associated disorders. It then discusses in vitro and in vivo evidence for selected species, extracts and compounds, including reported bioactive metabolites and proposed mechanisms of action when available. Finally, the most promising species, extracts and metabolites are highlighted, together with current limitations and future research needs regarding efficacy, safety, bioavailability, standardization and clinical relevance.eng
dc.description.sponsorshipUID/04326/2025; UID/PRR/04326/2025; UIDP/04326/2025
dc.identifier.doi10.3390/md24080262
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.1/29498
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationCentre for Marine and Environmental Research
dc.relation.ispartofMarine Drugs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDiabetes
dc.subjectHalophytes
dc.subjectInflammation
dc.subjectObesity
dc.subjectCardiovascular diseases
dc.subjectSecondary metabolites
dc.titleEthnomedicinal uses, phytochemistry and bioactivities of halophytes and salt-tolerant plants with potential against metabolic syndrome: a comprehensive revieweng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberLA/P/0101/2020
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.citation.issue8
oaire.citation.titleMarine Drugs
oaire.citation.volume24
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRodrigues
person.familyNameGuerreiro Pereira
person.familyNameCustódio
person.givenNameMaria João
person.givenNameCatarina Alexandra
person.givenNameLuísa
person.identifierR-004-VNG
person.identifierNmxO5SIAAAAJ
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id4512-3435-689C
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0002-1131-8773
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication12c32925-de9e-4289-bdd5-1d655d7a278c
relation.isAuthorOfPublication164572fc-85ed-4377-afd0-7ab4c8fdc79f
relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
relation.isAuthorOfPublication.latestForDiscovery12c32925-de9e-4289-bdd5-1d655d7a278c
relation.isProjectOfPublication794d4c77-c731-471e-bc96-5a41dcd3d872
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