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Antibacterial, antioxidant, and antiproliferative activities of corymbia citriodora and the essential oils of eight eucalyptus species

2018-06-21Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg15:Proteger a Vida Terrestre
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorMiguel, Maria da Graça
dc.contributor.authorGago, Custódia
dc.contributor.authorEstêvão, Maria Dulce da Mota Antunes de Oliveira
dc.contributor.authorLagoas, Soraia
dc.contributor.authorFaleiro, Maria Leonor
dc.contributor.authorMegías, Cristina
dc.contributor.authorCortés-Giraldo, Isabel
dc.contributor.authorVioque, Javier
dc.contributor.authorFigueiredo, Ana Cristina
dc.date.accessioned2026-02-24T10:21:31Z
dc.date.available2026-02-24T10:21:31Z
dc.date.issued2018-06-21
dc.description.abstractBackground: Essential oils (EOs) have shown antimicrobial, antioxidant, and antiproliferative activity, which may, alone or in combination with other substances, potentially be used for the development of new drugs. However, their chemical variability, depending on the species, varieties, or geographical origin (among other factors) determines different bioactivities that need to be evaluated. Methods: The antioxidant activity of Corymbia citriodora and eight Eucalyptus species EOs was determined using two different methods: the scavenging ability of 2,20 -azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS+• ) and peroxyl free radicals or oxygen radical absorbance capacity (ORAC). Antibacterial activity was evaluated using the microorganisms Streptococcus pneumoniae (strains D39 and TIGR4), and Haemophilus influenza (strain DSM 9999). The essential oils’ minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was assessed using a microdilution method. The antiproliferative activity was determined using the THP-1 cell line (human acute monocytic leukaemia) with methylthiazolyldiphenyl-tetrazolium bromide assay (MTT). Results: Corymbia citriodora and Eucalyptus viminalis EOs showed the highest ABTS and peroxyl free radical scavenging capacity. Eucalyptus globulus EO showed a high potential to treat Streptococcus pneumoniae infections. Haemophilus influenzae was the respiratory pathogen that showed the highest resistance to all EOs, including tea tree EO. After 96 h of incubation, at 25 µg/mL, Eucalyptus radiata and Eucalyptus viminalis EOs showed highest cytotoxic activity against the THP-1 cell line. Conclusions: Despite their specific bioactivities, no single EO showed simultaneously good antioxidant, antimicrobial, and antiproliferative activity.eng
dc.description.sponsorshipUID/AMB/50017-POCI-01-0145-FEDER-007638
dc.identifier.doi10.3390/medicines5030061
dc.identifier.issn2305-6320
dc.identifier.urihttp://hdl.handle.net/10400.1/28229
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationCenter for Mediterranean Bioresources and food
dc.relationCentre for Biomedical Research
dc.relation.ispartofMedicines
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCorymbia citriodora
dc.subjectEucalyptus dives
dc.subjectEucalyptus globulus
dc.subjectEucalyptus delegatensis subsp. tasmaniensis
dc.subjectEucalyptus pauciflora
dc.subjectEucalyptus radiata
dc.subjectEucalyptus smithii
dc.subjectEucalyptus urophylla
dc.subjectEucalyptus viminalis
dc.titleAntibacterial, antioxidant, and antiproliferative activities of corymbia citriodora and the essential oils of eight eucalyptus specieseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUID/BIA/04325/2013
oaire.awardNumberUID/BIM/04773/2013
oaire.awardTitleCenter for Mediterranean Bioresources and food
oaire.awardTitleCentre for Biomedical Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIA%2F04325%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIM%2F04773%2F2013/PT
oaire.citation.issue3
oaire.citation.titleMedicines
oaire.citation.volume5
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMiguel
person.familyNameGago
person.familyNameEstêvão
person.familyNameFaleiro
person.givenNameMaria da Graça
person.givenNameCustódia
person.givenNameMaria Dulce da Mota Antunes de Oliveira
person.givenNameMaria Leonor
person.identifierI-4695-2014
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person.identifier.ciencia-id6110-6FE7-DF28
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person.identifier.ciencia-id881B-53E8-0DB1
person.identifier.ciencia-id281D-5E01-F09A
person.identifier.orcid0000-0003-2507-4228
person.identifier.orcid0000-0001-9914-3615
person.identifier.orcid0000-0002-7151-8363
person.identifier.orcid0000-0002-3878-6948
person.identifier.ridG-8496-2019
person.identifier.scopus-author-id35562054500
person.identifier.scopus-author-id37060829600
person.identifier.scopus-author-id8381590400
person.identifier.scopus-author-id6507927018
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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