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Hydrothermal processing of laminaria ochroleuca for the production of crude extracts used to formulate polymeric nanoparticles

2020Journal article Open access
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dc.contributor.authorFlórez-Fernández, Noelia
dc.contributor.authorÁlvarez-Viñas, Milena
dc.contributor.authorGuerreiro, Filipa
dc.contributor.authorTorres, María Dolores
dc.contributor.authorGrenha, Ana
dc.contributor.authorDomínguez, Herminia
dc.date.accessioned2020-09-15T10:09:49Z
dc.date.available2020-09-15T10:09:49Z
dc.date.issued2020
dc.description.abstractA green extraction process using only water was proposed for the simultaneous extraction of alginate and bioactive compounds from Laminaria ochroleuca. Operation was carried out during non-isothermal heating up to maximal temperatures over the range of 70 °C to 100 °C. Once separated, the alginate and the crude extract were characterised and the biological activities and cytotoxicity of the extracts was studied, the latter in intestinal epithelial cells. Those alginates obtained at 90 °C exhibited the highest extraction yields and viscoelastic features of the corresponding hydrogels. The obtained results show that the extracts obtained by non-isothermal extraction were suitable to formulate nanoparticles, which showed the smallest size (≈ 250-350 nm) when the higher content of fucoidan extract was present. Given the evidenced properties, the extracts may find an application in the formulation of nanoparticulate carriers for drug delivery.pt_PT
dc.description.sponsorshipEuropean Union (EU): ED431G2019/06pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/md18070336pt_PT
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.1/14721
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCentre of Marine Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEnvironmentally friendly extraction technologiespt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectBioactive compoundspt_PT
dc.subjectPolymeric nanoparticlespt_PT
dc.titleHydrothermal processing of laminaria ochroleuca for the production of crude extracts used to formulate polymeric nanoparticlespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre of Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04326%2F2019/PT
oaire.citation.issue7pt_PT
oaire.citation.startPage336pt_PT
oaire.citation.titleMarine Drugspt_PT
oaire.citation.volume18pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFlórez-Fernández
person.familyNameGuerreiro
person.familyNameGrenha
person.givenNameNoelia
person.givenNameFilipa
person.givenNameAna
person.identifier.ciencia-idC21E-5E21-0A08
person.identifier.ciencia-idBF1D-7EFA-19BC
person.identifier.ciencia-id091C-0D58-7225
person.identifier.orcid0000-0002-2666-2315
person.identifier.orcid0000-0001-6224-1553
person.identifier.orcid0000-0002-2136-1396
person.identifier.ridI-1131-2015
person.identifier.ridH-1392-2017
person.identifier.scopus-author-id57192869367
person.identifier.scopus-author-id8607930100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationb88abfe8-e32c-477f-9fb0-5bdeca8a1a05
relation.isAuthorOfPublication1bd4d8f1-40e5-45af-b1e8-4b8e73a6a70d
relation.isAuthorOfPublication.latestForDiscovery1bd4d8f1-40e5-45af-b1e8-4b8e73a6a70d
relation.isProjectOfPublicationf38dbd9d-3734-4f3c-8d74-dff8dcaa8674
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