Matrix Gla protein expression: a complex process involving the use of alternative promoters, multiple splicing events and microRNAs

Cancela, Leonor; Laizé, Vincent; Conceição, N.; Tiago, Daniel; Maia,  Ana-Teresa; Bensimon-Brito, A.; Gavaia, Paulo J.

http://hdl.handle.net/10400.1/4469

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Resumo(s)

Matrix Gla protein (MGP) is a secreted vitamin K-dependent protein (VKD) located in the extracellular matrix and capable of binding calcium through its -carboxyglutamate residues. Although identified in 1983, transcriptional and post-transcriptional mechanisms regulating its expression remain unclear.

URI

http://hdl.handle.net/10400.1/4469

Citação

Cancela M.L., Laizé V., Conceição N., Tiago D.M., Maia A.T., Bensimon-Brito A., Gavaia P.J. 2012. Matrix Gla protein expression: a complex process involving the use of alternative promoters, multiple splicing events and microRNAs. FEBS International Workshop on New Developments in RNA Biology, September 1-4, Tavira, Portugal