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Cloning of the cDNA for sea bream (Sparus aurata) parathyroid hormone-related protein

2000Journal article Restricted access
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dc.contributor.authorFlanagan, J. A.
dc.contributor.authorPower, Deborah
dc.contributor.authorBendell, L. A.
dc.contributor.authorGuerreiro, P. M.
dc.contributor.authorFuentes, J.
dc.contributor.authorClark, M. S.
dc.contributor.authorCanario, Adelino V. M.
dc.contributor.authorDanks, J. A.
dc.contributor.authorBrown, B. L.
dc.contributor.authorIngleton, P. M.
dc.date.accessioned2014-05-14T08:48:27Z
dc.date.available2014-05-14T08:48:27Z
dc.date.issued2000
dc.date.updated2014-05-09T10:19:00Z
dc.description.abstractThis paper reports cloning of the cDNA for sea bream (Sparus aurata) parathyroid hormone-related protein (PTHrP). The gene codes for a 125-amino acid mature protein with a 35-residue prepeptide. The total gene sequence is 1.8 kb with approximately 75% noncoding. The N-terminus of the protein resembles mammalian and chicken PTHrP peptides with 12 of the first 21 amino acids identical and for which there is homology with mammalian parathyroid hormone. Toward the C-terminus, the nuclear transporter region between residues 79 and 93 in sea bream is 73% homologous to tetrapod PTHrP, and the RNA binding domain, 96–117, is 50% homologous, moreover starting with the conserved lysine and terminating with the lysine/arginine sequence. Sea bream PTHrP differs significantly from mammalian and chicken PTHrP, having a novel 16-amino acid segment between residues 38 and 54 and completely lacking the terminal domain associated in mammals with inhibition of bone matrix lysis. RT-PCR and in situ hybridization of sea bream tissues show that the gene is expressed widely and the results confirm observations of a PTHrP-like factor in sea bream detected with antisera to human PTHrP.por
dc.identifier.citationFlanagan, J.A.; Power, D.M.; Bendell, L.A.; Guerreiro, P.M.; Fuentes, J.; Clark, M.S.; Canario, A.V.M.; Danks, J.A.; Brown, B.L.; Ingleton, P.M. Cloning of the cDNA for Sea Bream (Sparus aurata) Parathyroid Hormone-Related Protein, General and Comparative Endocrinology, 118, 3, 373-382, 2000.por
dc.identifier.doihttp://dx.doi.org/10.1006/gcen.2000.7481
dc.identifier.issn0016-6480
dc.identifier.otherAUT: DPO00386; ACA00258;
dc.identifier.urihttp://hdl.handle.net/10400.1/3918
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherAcademic Presspor
dc.subjectPTHrPpor
dc.subjectGenepor
dc.subjectTeleostpor
dc.titleCloning of the cDNA for sea bream (Sparus aurata) parathyroid hormone-related proteinpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage382por
oaire.citation.issue3por
oaire.citation.startPage373por
oaire.citation.titleGeneral and Comparative Endocrinologypor
oaire.citation.volume118por
person.familyNamePower
person.familyNameGuerreiro da Costa Guerreiro
person.familyNameFuentes
person.familyNameCanario
person.givenNameDeborah Mary
person.givenNamePedro Miguel
person.givenNameJuan
person.givenNameAdelino
person.identifierA-2539-2009
person.identifier392998
person.identifier143624
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.ciencia-id5C13-965D-3148
person.identifier.ciencia-id421B-E196-2C33
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0003-1366-0246
person.identifier.orcid0000-0001-5371-7919
person.identifier.orcid0000-0003-0430-8734
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id7101806760
person.identifier.scopus-author-id7201832526
person.identifier.scopus-author-id56568523700
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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relation.isAuthorOfPublication.latestForDiscoveryd0a8a148-98e7-4899-8fb0-0b8afa91e4a4

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