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Advisor(s)
Abstract(s)
Sambucus nigra L. (S. nigra) is a shrub widespread in Europe and western Asia, traditionally
used in medicine, that has become popular in recent years as a potential source of a wide range
of interesting bioactive compounds. The aim of the present work was to develop a topical S. nigra
extract formulation based on ethosomes and thus to support its health claims with scientific evidence.
S. nigra extract was prepared by an ultrasound-assisted method and then included in ethosomes.
The ethosomes were analyzed in terms of their size, stability over time, morphology, entrapment
capacity (EC), extract release profile, stability over time and several biological activities. The prepared
ethosomes were indicated to be well defined, presenting sizes around 600 nm. The extract entrapment
capacity in ethosomes was 73.9 ± 24.8%, with an interesting slow extract release profile over 24 h. The
extract-loaded ethosomes presented collagenase inhibition activity and a very good skin compatibility
after human application. This study demonstrates the potential use of S. nigra extract incorporated in
ethosomes as a potential cosmeceutical ingredient and on further studies should be performed to
better understand the impact of S. nigra compounds on skin care over the time.
Description
Keywords
Sambucus nigra L Ethosomes Collagenase inhibition Skin compatibility
Citation
Pharmaceuticals 14 (5): 467 (2021)
Publisher
MDPI