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A newfangled collagenase inhibitor topical formulation based on Ethosomes with Sambucus nigra L. Extract

2021-05-15Journal article Open access
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dc.contributor.authorMota, Ana Henriques
dc.contributor.authorPrazeres, Inês
dc.contributor.authorMestre, Henrique
dc.contributor.authorBento-Silva, Andreia
dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorDuarte, Noélia
dc.contributor.authorSerra, Ana Teresa
dc.contributor.authorBronze, Maria Rosário
dc.contributor.authorRijo, Patrícia
dc.contributor.authorGaspar, Maria Manuela
dc.contributor.authorViana, Ana Silveira
dc.contributor.authorAscensão, Lia
dc.contributor.authorPinto, Pedro
dc.contributor.authorKumar, Pradeep
dc.contributor.authorAlmeida, António José
dc.contributor.authorReis, Catarina Pinto
dc.date.accessioned2021-05-26T12:08:57Z
dc.date.available2021-05-26T12:08:57Z
dc.date.issued2021-05-15
dc.date.updated2021-05-24T15:03:40Z
dc.description.abstractSambucus nigra L. (S. nigra) is a shrub widespread in Europe and western Asia, traditionally used in medicine, that has become popular in recent years as a potential source of a wide range of interesting bioactive compounds. The aim of the present work was to develop a topical S. nigra extract formulation based on ethosomes and thus to support its health claims with scientific evidence. S. nigra extract was prepared by an ultrasound-assisted method and then included in ethosomes. The ethosomes were analyzed in terms of their size, stability over time, morphology, entrapment capacity (EC), extract release profile, stability over time and several biological activities. The prepared ethosomes were indicated to be well defined, presenting sizes around 600 nm. The extract entrapment capacity in ethosomes was 73.9 ± 24.8%, with an interesting slow extract release profile over 24 h. The extract-loaded ethosomes presented collagenase inhibition activity and a very good skin compatibility after human application. This study demonstrates the potential use of S. nigra extract incorporated in ethosomes as a potential cosmeceutical ingredient and on further studies should be performed to better understand the impact of S. nigra compounds on skin care over the time.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifierdoi: 10.3390/ph14050467
dc.identifier.citationPharmaceuticals 14 (5): 467 (2021)pt_PT
dc.identifier.doi10.3390/ph14050467pt_PT
dc.identifier.eissn1424-8247
dc.identifier.urihttp://hdl.handle.net/10400.1/15502
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSambucus nigra Lpt_PT
dc.subjectEthosomespt_PT
dc.subjectCollagenase inhibitionpt_PT
dc.subjectSkin compatibilitypt_PT
dc.titleA newfangled collagenase inhibitor topical formulation based on Ethosomes with Sambucus nigra L. Extractpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue5pt_PT
oaire.citation.startPage467pt_PT
oaire.citation.titlePharmaceuticalspt_PT
oaire.citation.volume14pt_PT
person.familyNameRodrigues
person.givenNameMaria João
person.identifierR-004-VNG
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.orcid0000-0001-8732-710X
person.identifier.scopus-author-id56031608100
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication12c32925-de9e-4289-bdd5-1d655d7a278c
relation.isAuthorOfPublication.latestForDiscovery12c32925-de9e-4289-bdd5-1d655d7a278c

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