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Regulation of troponin T expression during muscle development in sea bream Sparus auratus Linnaeus: the potential role of thyroid hormones

2006Journal article Open access
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dc.contributor.authorCampinho, Marco António
dc.contributor.authorSweeney, Glen E.
dc.contributor.authorPower, Deborah
dc.date.accessioned2014-10-23T10:53:09Z
dc.date.available2014-10-23T10:53:09Z
dc.date.issued2006
dc.description.abstractIn the sea bream Sparus auratus three stage-specific fast troponin T (fTnT) isoforms have been cloned and correspond to embryonic-, larval- and adult-specific isoforms. Characterisation, using database searches, of the putative genomic organisation of Fugu rubripes and Tetraodon nigroviridis fTnT indicates that alternative exon splicing in the 59 region of the gene generates the different isoforms. Moreover, comparison of teleost fTnTs suggests that alternative splicing of fTnT appears to be common in teleosts. A different temporal expression pattern for each fTnT splice variant is found during sea bream development and probably relates to differing functional demands, as a highly acidic embryonic form (pI 5.16) is substituted by a basic larval form (pI 9.57). Thyroid hormones (THs), which play an important regulatory role in muscle development in flatfish and tetrapods, appear also to influence TnT gene expression in the sea bream. However, THs have a divergent action on different sea bream TnT genes and although the slow isoform (sTnT1) is TH-responsive, fTnT, sTnT2 and the itronless isoform (iTnT) are unaffected. The present results taken together with those published for flatfish seem to suggest differences may exist in the regulation of larval muscle development in teleosts.por
dc.description.sponsorshipThe authors thank Nádia Silva for her assistance in thyroid follicle analysis. This work has been carried out within the project Q4RS-1996-1442, ENDCONAQUA, with financial support from the Commission of the European Communities. However, it does not necessarily reflect the Commission’s views and in no way anticipates its future policy in this area. This project was further supported by Pluriannual funding to CCMAR by the Portuguese Science and Technology Council. M.A.C. was funded by the Portuguese Ministry of Science and Technology (SFRH/BD/6133/2001).por
dc.identifier.citationM. A. Campinho, G. E. Sweeney and D. M. Power, "Regulation of troponin T expression during muscle development in sea bream Sparus auratus Linnaeus. The potential role of thyroid hormones" in The Journal of Experimental Biology 209, 4751-4767.por
dc.identifier.doihttp://dx.doi.org/10.1242/jeb.02555
dc.identifier.issn0022-0949
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5426
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherCompany of Biologistspor
dc.relation.publisherversionhttp://jeb.biologists.org/content/209/23/4751.longpor
dc.subjectFast musclepor
dc.subjectSlow musclepor
dc.subjectSplice variantspor
dc.subjectTeleostpor
dc.subjectTemporal gene expression profilepor
dc.subjectThyroid hormonespor
dc.titleRegulation of troponin T expression during muscle development in sea bream Sparus auratus Linnaeus: the potential role of thyroid hormonespor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4767por
oaire.citation.issuePt. 23por
oaire.citation.startPage4751por
oaire.citation.titleJournal of Experimental Biologypor
oaire.citation.volume209por
person.familyNameCampinho
person.familyNamePower
person.givenNameMarco António
person.givenNameDeborah Mary
person.identifier.ciencia-id0E18-2560-6EC1
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-5238-0506
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridD-8833-2013
person.identifier.scopus-author-id8938999600
person.identifier.scopus-author-id7101806760
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationf8e8c466-6a6f-4ccf-b96d-34565fe53b6c
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryf8e8c466-6a6f-4ccf-b96d-34565fe53b6c

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