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Nanomedicine in oncology: diagnostic breakthroughs and therapeutic Frontiers

2025-10Journal article Open access
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dc.contributor.authorShehzad, Adeeb
dc.contributor.authorAlves, Júlia
dc.contributor.authorUl-Islam, Mazhar
dc.contributor.authorSaidi, Abdullah Khamis Al
dc.contributor.authorDuarte, Sofia O. D.
dc.contributor.authorKhan, Mohammad Sherjeel Javed
dc.contributor.authorFonte, Pedro
dc.date.accessioned2025-09-30T08:47:09Z
dc.date.available2025-09-30T08:47:09Z
dc.date.issued2025-10
dc.description.abstractNanomedicine is a multidisciplinary field, offering significant promises for cancer detection and therapy. Nanoparticles (NPs), nanoprobes and nanobiosensors can be tailored to achieve highly sensitive tumor detection by contrast imaging techniques. The application of directed drug delivery for cancer therapies can be achieved via the formulation and tailoring of drug-loaded nanocarriers. NPs have been employed as carrier to transport drugs or biological molecules to tumor tissues via active or passive mechanisms, consequently improving treatment outcomes and minimize harmful effects. However, nanomedicine translation has been hindered by augmented permeability and retention and ICI of the TME, limiting improvement and potential outcomes of patients. TME, consisting of cancerous cells, CAFs or TAFs, specific immune cells, and the stroma, performs a crucial part in contributing to cancer resistance to nanotherapy. This review summarizes nanotechnology application in the identification and treatment of cancers by exploring pathophysiological features, mechanisms and limitation of nanomedicine in cancer.eng
dc.identifier.doi10.1016/j.nano.2025.102854
dc.identifier.issn1549-9634
dc.identifier.urihttp://hdl.handle.net/10400.1/27756
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relationInstitute for Bioengineering and Biosciences
dc.relationInstitute for Bioengineering and Biosciences
dc.relationInstitute for Health and Bioeconomy
dc.relation.ispartofNanomedicine: Nanotechnology, Biology and Medicine
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNanotechnology
dc.subjectCancer
dc.subjectDiagnosis
dc.subjectTherapy
dc.subjectImmunotherapy
dc.subjectChemotherapy
dc.titleNanomedicine in oncology: diagnostic breakthroughs and therapeutic Frontierseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04565%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04565%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT
oaire.citation.startPage102854
oaire.citation.titleNanomedicine: Nanotechnology, Biology and Medicine
oaire.citation.volume69
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFonte
person.givenNamePedro
person.identifier.ciencia-id2410-123D-3385
person.identifier.orcid0000-0002-1115-9282
person.identifier.ridK-3215-2013
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
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