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The Ocean’s pharmacy: Health discoveries in marine algae

2024-04-22Journal article Open access
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dc.contributor.authorSilva, Mélanie
dc.contributor.authorAvni, Dorit
dc.contributor.authorVarela, João
dc.contributor.authorBarreira, Luísa
dc.date.accessioned2024-05-07T11:34:08Z
dc.date.available2024-05-07T11:34:08Z
dc.date.issued2024-04-22
dc.date.updated2024-04-26T13:09:26Z
dc.description.abstractNon-communicable diseases (NCDs) represent a global health challenge, constituting a major cause of mortality and disease burden in the 21st century. Addressing the prevention and management of NCDs is crucial for improving global public health, emphasizing the need for comprehensive strategies, early interventions, and innovative therapeutic approaches to mitigate their far-reaching consequences. Marine organisms, mainly algae, produce diverse marine natural products with significant therapeutic potential. Harnessing the largely untapped potential of algae could revolutionize drug development and contribute to combating NCDs, marking a crucial step toward natural and targeted therapeutic approaches. This review examines bioactive extracts, compounds, and commercial products derived from macro- and microalgae, exploring their protective properties against oxidative stress, inflammation, cardiovascular, gastrointestinal, metabolic diseases, and cancer across in vitro, cell-based, in vivo, and clinical studies. Most research focuses on macroalgae, demonstrating antioxidant, anti-inflammatory, cardioprotective, gut health modulation, metabolic health promotion, and anti-cancer effects. Microalgae products also exhibit anti-inflammatory, cardioprotective, and anti-cancer properties. Although studies mainly investigated extracts and fractions, isolated compounds from algae have also been explored. Notably, polysaccharides, phlorotannins, carotenoids, and terpenes emerge as prominent compounds, collectively representing 42.4% of the investigated compounds.pt_PT
dc.description.sponsorship2022.12681.BDANA; EC/H2020/101000501/EUpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMolecules 29 (8): 1900 (2024)pt_PT
dc.identifier.doi10.3390/molecules29081900pt_PT
dc.identifier.eissn1420-3049
dc.identifier.urihttp://hdl.handle.net/10400.1/20712
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHealthpt_PT
dc.subjectBioactivitypt_PT
dc.subjectAlgaept_PT
dc.subjectMicroalgaept_PT
dc.subjectMacroalgaept_PT
dc.subjectNon-communicable diseasespt_PT
dc.subjectIn vivo studiespt_PT
dc.subjectIn vitro studiespt_PT
dc.subjectCell assayspt_PT
dc.titleThe Ocean’s pharmacy: Health discoveries in marine algaept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.citation.issue8pt_PT
oaire.citation.startPage1900pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume29pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSilva
person.familyNameVarela
person.familyNameBarreira
person.givenNameMélanie
person.givenNameJoão
person.givenNameLuísa
person.identifier.ciencia-id6D1A-17E5-1400
person.identifier.orcid0000-0002-0460-646X
person.identifier.orcid0000-0003-3101-693X
person.identifier.orcid0000-0002-4077-855X
person.identifier.ridM-4223-2013
person.identifier.scopus-author-id55741416000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationd339a9e7-bc32-49c4-ba48-a17343d40092
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relation.isAuthorOfPublication.latestForDiscoveryd339a9e7-bc32-49c4-ba48-a17343d40092
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