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Effects of estrogens and estrogenic disrupting compounds on fish mineralized tissues

2014-08Journal article Open access
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dc.contributor.authorPinto, Patricia IS
dc.contributor.authorEstevao, Maria D.
dc.contributor.authorPower, Deborah M.
dc.date.accessioned2018-12-07T14:52:40Z
dc.date.available2018-12-07T14:52:40Z
dc.date.issued2014-08
dc.description.abstractEstrogens play well-recognized roles in reproduction across vertebrates, but also intervene in a wide range of other physiological processes, including mineral homeostasis. Classical actions are triggered when estrogens bind and activate intracellular estrogen receptors (ERs), regulating the transcription of responsive genes, but rapid non-genomic actions initiated by binding to plasma membrane receptors were recently described. A wide range of structurally diverse compounds from natural and anthropogenic sources have been shown to interact with and disrupt the normal functions of the estrogen system, and fish are particularly vulnerable to endocrine disruption, as these compounds are frequently discharged or run-off into waterways. The effect of estrogen disruptors in fish has mainly been assessed in relation to reproductive endpoints, and relatively little attention has been given to other disruptive actions. This review will overview the actions of estrogens in fish, including ER isoforms, their expression, structure and mechanisms of action. The estrogen functions will be considered in relation to mineral homeostasis and actions on mineralized tissues. The impact of estrogenic endocrine disrupting compounds on fish mineralized tissues will be reviewed, and the potential adverse outcomes of exposure to such compounds will be discussed. Current lacunae in knowledge are highlighted along with future research priorities.
dc.description.sponsorshipFoundation for Science and Technology of Portugal (FCT) [PTDC/AAG-GLO/4003/2012, PEst-C/MAR/LA0015/2011, SFRH/BPD/25247/2005]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.3390/md12084474
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.1/11158
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI Ag
dc.relationE2SCALE: Scaling-down estrogenic responses in fish
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTrout Oncorhynchus-Mykiss
dc.subjectReceptor messenger-Rna
dc.subjectRainbow-Trout
dc.subjectEndocrine disruption
dc.subjectOsteoblastic activities
dc.subjectBinding affinities
dc.subjectCortical Bone
dc.subjectTeleost fish
dc.subjectFundulus-Heteroclitus
dc.subjectCalcium Mobilization
dc.titleEffects of estrogens and estrogenic disrupting compounds on fish mineralized tissues
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleE2SCALE: Scaling-down estrogenic responses in fish
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAAG-GLO%2F4003%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F25247%2F2005/PT
oaire.citation.endPage4494
oaire.citation.issue8
oaire.citation.startPage4474
oaire.citation.titleMarine drugs
oaire.citation.volume12
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
person.familyNamePinto
person.familyNameEstêvão
person.familyNamePower
person.givenNamePatricia IS
person.givenNameMaria Dulce da Mota Antunes de Oliveira
person.givenNameDeborah Mary
person.identifier643457
person.identifierI-4695-2014
person.identifier.ciencia-idE51D-5CCB-B1C6
person.identifier.ciencia-id881B-53E8-0DB1
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0001-7854-3898
person.identifier.orcid0000-0002-7151-8363
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-3817-2013
person.identifier.scopus-author-id10240774300
person.identifier.scopus-author-id8381590400
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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