Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts

Rafael, Marta S.; Laizé, Vincent; Florindo, C.; Ferraresso, Serena; Bargelloni, Luca; Cancela, Leonor

http://hdl.handle.net/10400.1/4284

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Abstract(s)

FHL2 is a multifunctional protein involved in gene transcription regulation and cytoarchitecture modulation that has been recently associated with epithelial-mesenchymal transition (EMT) in colon cancer. Overexpression of FHL2 in a fish pre-osteoblastic cell line promoted cell dedifferentiation and impaired its extracellular matrix mineralization capacity. Cell cultures also acquired a novel threedimensional structure organization, their proliferation rate was enhanced and gene expression profile was altered in agreement with an EMT-like phenotype upon overexpression of FHL2. Altogether, our results provide additional support to the relevance of FHL2 for cell differentiation and its association with hallmarks of cancer phenotype.

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http://hdl.handle.net/10400.1/4284

Citation

Rafael, M.S.; Laizé, V.; Florindo, C.; Ferraresso, S.; Bargelloni, L.; Cancela, M.L.Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts, Biochimie, 94, 5, 1128-11, 2012.