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Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts

2012-05Journal article Restricted access
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dc.contributor.authorRafael, Marta S.
dc.contributor.authorLaizé, Vincent
dc.contributor.authorFlorindo, C.
dc.contributor.authorFerraresso, Serena
dc.contributor.authorBargelloni, Luca
dc.contributor.authorCancela, Leonor
dc.date.accessioned2014-06-12T13:49:56Z
dc.date.available2014-06-12T13:49:56Z
dc.date.issued2012-05
dc.date.updated2014-06-03T09:41:08Z
dc.description.abstractFHL2 is a multifunctional protein involved in gene transcription regulation and cytoarchitecture modulation that has been recently associated with epithelial-mesenchymal transition (EMT) in colon cancer. Overexpression of FHL2 in a fish pre-osteoblastic cell line promoted cell dedifferentiation and impaired its extracellular matrix mineralization capacity. Cell cultures also acquired a novel threedimensional structure organization, their proliferation rate was enhanced and gene expression profile was altered in agreement with an EMT-like phenotype upon overexpression of FHL2. Altogether, our results provide additional support to the relevance of FHL2 for cell differentiation and its association with hallmarks of cancer phenotype.por
dc.identifier.citationRafael, M.S.; Laizé, V.; Florindo, C.; Ferraresso, S.; Bargelloni, L.; Cancela, M.L.Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts, Biochimie, 94, 5, 1128-11, 2012.por
dc.identifier.doihttp://dx.doi.org/10.1016/j.biochi.2012.01.013
dc.identifier.issn0300-9084
dc.identifier.otherAUT: LCA00739
dc.identifier.urihttp://hdl.handle.net/10400.1/4284
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://ac.els-cdn.com/S0300908412000156/1-s2.0-S0300908412000156-main.pdf?_tid=1e976124-f238-11e3-9c1c-00000aab0f26&acdnat=1402581039_97e7a82e70e678d0ac976f0d05c9d4fcpor
dc.titleOverexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblastspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1134por
oaire.citation.issue5por
oaire.citation.startPage1128por
oaire.citation.titleBiochimiepor
oaire.citation.volume94por
person.familyNameRafael
person.familyNameLaizé
person.familyNameCancela
person.givenNameMarta
person.givenNameVincent
person.givenNameM. Leonor
person.identifier.ciencia-id1C10-BF17-0DD7
person.identifier.orcid0000-0002-5518-9790
person.identifier.orcid0000-0001-9565-9198
person.identifier.orcid0000-0003-3114-6662
person.identifier.ridB-4463-2008
person.identifier.scopus-author-id15078212800
person.identifier.scopus-author-id6602982778
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicatione4c6f8da-c3f6-4eee-bf78-f023843c343b
relation.isAuthorOfPublicationb51cd3d5-7ee4-47d8-9bc4-b3e297aa222f
relation.isAuthorOfPublicationb9bbfe32-3dfe-4131-ad14-a4394008447f
relation.isAuthorOfPublication.latestForDiscoveryb9bbfe32-3dfe-4131-ad14-a4394008447f

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