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Accumulation of phenolic compounds in in vitro cultures and wild plants of Lavandula viridis L'Her and their antioxidant and anti-cholinesterase potential

dc.contributor.authorCosta, Patrícia
dc.contributor.authorGonçalves, Sandra
dc.contributor.authorValentão, Patrícia
dc.contributor.authorAndrade, Paula B.
dc.contributor.authorRomano, Anabela
dc.date.accessioned2015-06-18T10:12:33Z
dc.date.available2015-06-18T10:12:33Z
dc.date.issued2013
dc.description.abstractIn this study, we evaluated the phenolic profile, antioxidant and anti-cholinesterase potential of different extracts from wild plants and in vitro cultures of Lavandula viridis L'Her. The HPLC-DAD analysis allowed the identification and quantification of 3-0-caffeoylquinic, 4-0-caffeoylquinic, 5-0-caffeoylquinic and rosmarinic acids, and luteolin and pinocembrin. Water/ethanol extract from in vitro cultures contained the highest amount of the identified phenolic compounds (51652.92 mg/kg). To investigate the antioxidant activity we used Trolox equivalent antioxidant capacity, oxygen radical absorbance capacity, Fe2+ chelation activity and the inhibition of Fe2+-induced lipid peroxidation in mouse brain homogenates (in vitro). Overall, all the extracts from both wild plants and in vitro cultures exhibited ability to scavenge free radicals, to chelate Fe2+ and to protect against lipid peroxidation. In addition, the extracts from L. viridis were active in inhibiting both acetylcholinesterase and butyrylcholinesterase (Ellman's method). Our findings suggest that L. viridis in vitro cultures represent a promising alternative for the production of active metabolites with antioxidant and anti-cholinesterase activity. (C) 2013 Elsevier Ltd. All rights reserved.
dc.identifier.doihttp://dx.doi.org/10.1016/j.fct.2013.03.006
dc.identifier.issn0278-6915
dc.identifier.otherAUT: ARO01015;
dc.identifier.urihttp://hdl.handle.net/10400.1/6396
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier / Pergamon
dc.relation.isbasedonP-006-9PN
dc.subjectIn vitro cultures
dc.subjectPhenolic compounds
dc.subjectRosmarinic acid
dc.subjectFree radical scavenging
dc.subjectAnti-cholinesterase activity
dc.subjectWild plants
dc.titleAccumulation of phenolic compounds in in vitro cultures and wild plants of Lavandula viridis L'Her and their antioxidant and anti-cholinesterase potential
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage74
oaire.citation.startPage69
oaire.citation.titleFood and Chemical Toxicology
oaire.citation.volume57
person.familyNameGonçalves
person.familyNameRomano
person.givenNameSandra
person.givenNameAnabela
person.identifier.ciencia-id9F19-E3AE-2C59
person.identifier.ciencia-id8A18-7E9A-3B0E
person.identifier.orcid0000-0002-3038-4434
person.identifier.orcid0000-0002-7204-7428
person.identifier.ridM-6988-2017
person.identifier.scopus-author-id8583003200
person.identifier.scopus-author-id56249997600
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublicationa8b335b2-45cc-4578-89b0-153273014280
relation.isAuthorOfPublicatione3343b60-17d3-4f5e-a2bf-06f26da69206
relation.isAuthorOfPublication.latestForDiscoverye3343b60-17d3-4f5e-a2bf-06f26da69206

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