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Can Subjective Memory Complaints Identify A beta Positive and A beta Negative Amnestic Mild Cognitive Impairment Patients?

2019Journal article Restricted access
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dc.contributor.authorMendes, Tiago
dc.contributor.authorCardoso, Sandra
dc.contributor.authorGuerreiro, Manuela
dc.contributor.authorMaroco, Joao
dc.contributor.authorSilva, Dina
dc.contributor.authorAlves, Luisa
dc.contributor.authorSchmand, Ben
dc.contributor.authorGerardo, Bianca
dc.contributor.authorLima, Marisa
dc.contributor.authorSantana, Isabel
dc.contributor.authorde Mendonca, Alexandre
dc.date.accessioned2020-07-24T10:53:12Z
dc.date.available2020-07-24T10:53:12Z
dc.date.issued2019
dc.description.abstractBackground: The use of biomarkers, in particular amyloid-beta (A(beta) changes, has allowed the possibility to identify patients with subjective memory complaints (SMCs) and amnestic mild cognitive impairment (aMCI) who suffer from Alzheimer's disease (AD). Since it is unfeasible that all patients with aMCI could presently undergo biomarkers assessment, it would be important that SMCs might contribute to identify the aMCI patients who have AD amyloid pathology. Objectives: To know whether aMCI patients with amyloid biomarkers (A beta(+)) present greater SMCs as compared to those without amyloid biomarkers (A beta(-)). Methods: Participants were selected from a cohort of nondemented patients with cognitive complaints and a comprehensive neuropsychological evaluation, on the basis of 1) diagnosis of aMCI
dc.description.abstract2) detailed assessment of memory difficulties with the SMC Scale
dc.description.abstractand 3) known amyloid status. The amyloid status was determined on the basis of either CSF A beta(1-42) concentration or amyloid PET imaging. Results: Of the 176 patients with aMCI studied, 90 were A beta(+) and 86 were A. . The two groups did not differ in terms of age, gender, and education. The SMC total score was not significantly different in the A beta(+) aMCI patients (9.48 +/- 4.18) when compared to the A beta(-) aMCI patients (10.52 +/- 4.57). The A beta(+) aMCI patients had lower scores on the MMSE and memory/learning tests, but not on the Geriatric Depression Scale, when comparing to the A beta(-) aMCI patients. Conclusions: Evaluating SMCs does not seem helpful to identify, among patients with aMCI, those who have AD.
dc.description.sponsorshipFundacao para a Ciencia e Tecnologia (FCT)Portuguese Foundation for Science and Technology [PTDC/MED-NEU/27946/2017]
dc.identifier.doi10.3233/JAD-190414
dc.identifier.issn1387-2877
dc.identifier.issn1875-8908
dc.identifier.urihttp://hdl.handle.net/10400.1/14464
dc.language.isoeng
dc.peerreviewedyes
dc.publisherIos Press
dc.subjectAlzheimers-Disease
dc.subjectAmyloid-Beta
dc.subjectOlder-People
dc.subjectAnosognosia
dc.subjectDiagnosis
dc.subjectDementia
dc.subjectAssociation
dc.subjectPopulation
dc.subjectPrevalence
dc.subjectDepression
dc.titleCan Subjective Memory Complaints Identify A beta Positive and A beta Negative Amnestic Mild Cognitive Impairment Patients?
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1111
oaire.citation.issue4
oaire.citation.startPage1103
oaire.citation.titleJournal of Alzheimers Disease
oaire.citation.volume70
person.familyNameSilva
person.givenNameDina
person.identifier.orcid0000-0003-4437-2765
person.identifier.scopus-author-id26657734400
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublicationadb36ab3-1d97-48a3-b8df-544bef7c7aa0
relation.isAuthorOfPublication.latestForDiscoveryadb36ab3-1d97-48a3-b8df-544bef7c7aa0

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