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In vitro behaviour of konjac glucomannan microparticles aimed at pulmonary tuberculosis therapy

2020-04Conference object Restricted access
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dc.contributor.authorGuerreiro, Filipa
dc.contributor.authorSwedrowska, Magda
dc.contributor.authorRosa Da Costa, Ana
dc.contributor.authorGrenha, Ana
dc.contributor.authorForbes, Ben
dc.date.accessioned2021-06-24T11:35:46Z
dc.date.available2021-06-24T11:35:46Z
dc.date.issued2020-04
dc.description.abstractTuberculosis is one of the highest causes of death worldwide. Long periods of treatment are required and result in some cases in therapeutic incompliance, potentiating the development of multidrug-resistant tuberculosis. Thus, new approaches to treat the infection are required as an alternative to conventional orally administered treatment. This work proposes the development of an inhalable system, which is specifically targeted to alveolar macrophages, where the Mycobacterium tuberculosis is located. The targeting is mainly driven by the selected matrix material, konjac glucomannan (KGM), a natural polymer comprising mannan units that are expected to potentiate phagocytosis. Microparticles were loaded with two antitubercular drugs, isoniazid (INH) and rifabutin (RFB). KGM/INH/RFB microparticles were produced by spray-drying to produce particles with suitable characteristics to deliver INH and RFB to the alveolar region. The KGM/INH/RFB microparticles possessed an aerodynamic diameter of approximately 3 µm, meeting the requirement of a therapy targeted to alveolar macrophages. Moreover, KGM microparticles exhibited suitable geometric size (2.24 µm) and shape (spherical) to be phagocytosed to deliver drugs to infected macrophages. INH and RFB were associated with KGM microparticles with efficiencies of 91% and 74%, respectively. Similar in vitro release profiles were observed for both drugs in simulated lung fluid (SLF) replicating the lining fluid composition found in human alveoli.
dc.description.sponsorshipFunding from the Portuguese Foundation for Science and Technology (UID/Multi/04326/2019, UID/BIM/04773/2013, Pest-OE/QUI/UI4023/2014), and the PhD scholarship to Filipa Guerreiro (SFRH/BD/115628/2016) are acknowledged.
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.issn1941-2711
dc.identifier.urihttp://hdl.handle.net/10400.1/16530
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMary Ann Liebert
dc.subject.otherRespiratory system
dc.titleIn vitro behaviour of konjac glucomannan microparticles aimed at pulmonary tuberculosis therapy
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FQUI%2FUI4023%2F2014/PT
oaire.citation.endPageA12
oaire.citation.issue2
oaire.citation.titleJournal of Aerosol Medicine and Pulmonary Drug Delivery
oaire.citation.volume33
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameGuerreiro
person.familyNameRosa da Costa
person.familyNameGrenha
person.givenNameFilipa
person.givenNameAna M
person.givenNameAna
person.identifier305029
person.identifier.ciencia-idBF1D-7EFA-19BC
person.identifier.ciencia-idA418-A85E-5DB1
person.identifier.ciencia-id091C-0D58-7225
person.identifier.orcid0000-0001-6224-1553
person.identifier.orcid0000-0003-0225-9537
person.identifier.orcid0000-0002-2136-1396
person.identifier.ridE-2165-2012
person.identifier.ridH-1392-2017
person.identifier.scopus-author-id53986075100
person.identifier.scopus-author-id8607930100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typeconferenceObject
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