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Effect of omega-3 fatty acids supplementation on adipokines: a systematic review and meta-analysis of randomized controlled trials

2022-09-22Review Restricted access
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dc.contributor.authorSepidarkish, Mahdi
dc.contributor.authorRezamand, Gholamreza
dc.contributor.authorQorbani, Mostafa
dc.contributor.authorHeydari, Hafez
dc.contributor.authorEstêvão, M. Dulce
dc.contributor.authorOmran, Dalia
dc.contributor.authorMorvaridzadeh, Mojgan
dc.contributor.authorRoffey, Darren M.
dc.contributor.authorFarsi, Farnaz
dc.contributor.authorEbrahimi, Sara
dc.contributor.authorShokri, Fatemeh
dc.contributor.authorHeshmati, Javad
dc.date.accessioned2021-09-08T10:57:58Z
dc.date.available2021-09-08T10:57:58Z
dc.date.issued2022-09-22
dc.description.abstractBackground Although a large body of literature reported the beneficial effects of omega-3 fatty acids (omega-3 FAs) consumption on adipokines levels, but recent findings from clinical trials are not univocal. The aim of this systematic review and meta-analysis was to evaluate the effect of omega-3 FAs supplements on adipokines. Methods We searched Medline, Web of Science, Scopus, Embase, and Cochrane Library from inception to August 2020 without any particular language limitations. Outcomes were summarized as standardized mean difference (SMD) with 95% confidence intervals (CIs) estimated from Hedge's g and random effects modeling. Results Fifty-two trials involving 4,568 participants were included. Omega-3 FAs intake was associated with a significant increase in plasma adiponectin levels (n = 43; 3,434 participants; SMD: 0.21, 95% CI: 0.04, 0.37; p = 0.01; I-2= 80.14%). This meta-analysis indicates that supplementing participants with omega-3 fatty acids more than 2000 mg daily and more than 10 weeks resulted in a significant and more favorable improvement in plasma adiponectin levels. However, omega-3 FAs intake had no significant effect on leptin levels (SMD: -0.02, 95% CI: -0.20, 0.17, I-2= 54.13%). Conclusion The evidence supports a beneficial effect of omega-3 FAs intake on serum adiponectin levels but does not appear to impact on leptin concentrations. Larger well-designed RCTs are still required to evaluate the effect of omega-3 FAs on leptin in specific diseases.
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1080/10408398.2021.1915743
dc.identifier.issn1040-8398
dc.identifier.urihttp://hdl.handle.net/10400.1/16990
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTAYLOR & FRANCIS INC
dc.subjectAdipokines
dc.subjectAdiponectin
dc.subjectMeta-analysis
dc.subjectOmega-3 FAs
dc.subjectLeptin
dc.subjectSystematic review
dc.subject.otherFood Science & Technology; Nutrition & Dietetics
dc.titleEffect of omega-3 fatty acids supplementation on adipokines: a systematic review and meta-analysis of randomized controlled trials
dc.typereview
dspace.entity.typePublication
oaire.citation.titleCritical Reviews in Food Science and Nutrition
person.familyNameEstêvão
person.givenNameMaria Dulce da Mota Antunes de Oliveira
person.identifierI-4695-2014
person.identifier.ciencia-id881B-53E8-0DB1
person.identifier.orcid0000-0002-7151-8363
person.identifier.scopus-author-id8381590400
rcaap.rightsrestrictedAccess
rcaap.typereview
relation.isAuthorOfPublication67887883-2695-48cc-8221-aa46780ac143
relation.isAuthorOfPublication.latestForDiscovery67887883-2695-48cc-8221-aa46780ac143

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