Loading...
Publication
Pharmacogenetic analysis of the Programmed cell death 6-interacting protein in Chinese individuals
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 1.72 MB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
Introduction:
Pharmacogenetics is the study of germline genetic variation resulting in altered absorption, distribution, metabolism and excretion associated with the efficacy or toxicity of a drug, or affecting drug interaction with the target protein. Cancer is one of the top ten leading causes of death globally. Moreover lung cancer is one of the most commonly diagnosed cancer, most patients with NSCLC are being diagnose in a late stage and lost the opportunity of surgery. Platinum –based regimens in overall survival and quality of life shown meagre improvement. Study on single nucleotide polymorphism (SNP) showing significant improvement on detecting risk of lung cancer and overall survival by study and by measure and evaluate molecularly defined biomarkers.
Results:
A total of 335 lung cancer patients, the number of responders (CR or PR) were 100 and non-responders (PD or SD) were 235. All patients received platinum-based chemotherapy, cisplatin-based was 153(45.7%) and carboplatin-based was 182(44.3%). age (P-value 0.037), histology (0.022) and ECOG (0.033) may be considered statistically significant risk factors on platinum-based chemotherapy efficacy in all population. The rs31839825 SNP showed a significant association with chemotherapy response when considering the additive model (OR=0.67, P=0.033). The relationship of the SNP with response to chemotherapy showed significant associations with chemotherapy response: for stage I-II in additive (OR=1.89, P=0.017) and dominant (OR=2.1, P=0.014) models, for EAC in additive model (OR=0.83, P=0.041), for non-smoking (OR=0.47, P=0.048), and for cisplatin (OR=0.51, P=0.046) in recessive model.
Conclusion:
Results prove that there is a correlation between response and resistance to platinum based chemotherapy. It also suggests that there is a connection between resistance to a drug and the histology and association between the gene polymorphism and lung cancer risk or chemo sensitivity. More studies need to be performed to investigate the potential linking rs3183982 polymorphism in PDCD6IP encoding protein required for apoptosis with cancer progression and prognosis
Description
Dissertação de Mestrado, Mestrado em Qualidade em Análises, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2015