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Advisor(s)
Abstract(s)
Parathyroid hormone-related protein (PTHrP) and somatolactin (SL) are both peptides
that have been located in PAS+ve pars intermedia (PI) cells of teleost fishes.
In mammals and the chick PTHrP is a hypercalcaemic factor causing lysis of bone
calcified matrix and inhibiting phosphate excretion via the kidney. Functions of
PTHrP in fishes are unknown but SL stimulates phosphate re-absorption by flounder
kidney tubule cells1 and low ambient calcium activates PI cells of trout pituitaries.2
It appears possible that both peptides have some similar functions. They only share
incidental amino acid homologies, so we have examined brain and pituitaries of sea
bream for their distribution using specific antiserum to chum salmon SL (generous
gift of H. Kawauchi) and to two regions of human PTHrP (1–16 ) and (50–69).
Description
Keywords
Parathyroid hormone-related protein
Citation
P.M. INGLETON, D.M. POWER, A.V. M. CANARIO, T.J. MARTIN and J.A. DANKS, "Parathyroid hormone-related protein and somatolactin in sea bream (Sparus aurata) brain and pituitary" in Annals of the New York Academy of Sciences Volume 839, TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY: FROM MOLECULAR TO INTEGRATIVE BIOLOGY pages 370–371, May 1998.
Publisher
Wiley