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Portuguese recommendations for the management of transthyretin amyloid cardiomyopathy (Part 1 of 2): screening, diagnosis and treatment. Developed by the task force on the management of transthyretin amyloid cardiomyopathy of the working group on myocardial and pericardial diseases of the portuguese society of cardiology
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Resumo(s)
The Portuguese recommendations for the management of transthyretin amyloid cardiomyopathy (ATTR-CM) evaluate and summarize the available evidence and provide evidence-based recommendations on the best management of patients with ATTR-CM. These recommendations represent the official position of the Working Group on Myocardial and Pericardial Diseases (WGMPD) of the Portuguese Society of Cardiology. The Portuguese WGMPD selected the members of this Task Force as expert professionals involved in the care of patients with this disease. The Task Force performed a critical evaluation of the available evidence on the diagnostic procedures and therapeutic options for ATTR-CM, including an assessment of risk-benefit ratios. The strength of every recommendation and its level of evidence were weighed and scored according to predefined scales, usually those used by the European Society of Cardiology (ESC) in their guidelines, as outlined below in Tables 1 and 2. This Task Force followed voting procedures, and all approved recommendations were subject to a vote and achieved at least 75% agreement among voting members. The experts of the writing panels provided declaration of interest forms for all relationships that might be perceived as actual or potential sources of conflicts of interest. These recommendations were developed without any financial support or involvement of the healthcare industry. The Portuguese WGMPD supervised and coordinated the preparation of these recommendations and was responsible for the approval process. After appropriate revisions, the recommendations were signed off by all the experts involved in the Task Force. The WGMPD submitted the final document for publication in the official journal of the Portuguese Society of Cardiology, Revista Portuguesa de Cardiologia (Portuguese Journal of Cardiology). The recommendations were developed after careful consideration of the scientific knowledge and evidence available at the time of writing. Tables of recommendations are provided in this document along with the corresponding class of recommendation and level of evidence for each statement. Specific areas on which there are uncertainties concerning the existing evidence for the recommendation were also identified. The Task Force members carried out systematic reviews of the literature on these topics, which will be provided in separate publications. These recommendations do not override the individual responsibility of health professionals to make appropriate and accurate decisions in consideration of each individual patient’s health condition.
Descrição
Palavras-chave
Amyloidosis Cardiac amyloidosis Transthyretin amyloid cardiomyopathy Transthyretin Diagnosis Screening Treatment Recommendations
Contexto Educativo
Citação
Editora
Sociedade Portuguesa de Cardiologia