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Hetero-Diels-Alder approach to Bis(indolyl)methanes

2017-02Journal article Restricted access
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dc.contributor.authorGrosso, Carla
dc.contributor.authorCardoso, Ana L.
dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorMarques, Catia
dc.contributor.authorBarreira, Luísa
dc.contributor.authorLemos, Americo
dc.contributor.authorPinho e Melo, Teresa M. D. V.
dc.date.accessioned2019-11-20T15:07:49Z
dc.date.available2019-11-20T15:07:49Z
dc.date.issued2017-02
dc.description.abstractA novel synthetic approach to bis(indolyl)methanes has been established. Our one-pot synthetic strategy based on two consecutive hetero-Diels-Alder cycloaddition reactions of electrophilic conjugated nitrosoalkenes with indoles was extended to a range of new 1-hydroxyiminomethyl-bis(indolyl) methanes. Furthermore, a similar and broad range approach was applied to the synthesis of previously unknown 1-hydrazonomethyl-bis(indolyl)methanes. The biological evaluation of the new bis(indolyl) methanes as anti-cancer agents was investigated. (C) 2016 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipCoimbra Chemistry Centre [CQC-QO-BPD-2015]
dc.identifier.doi10.1016/j.bmc.2016.12.028
dc.identifier.issn0968-0896
dc.identifier.issn1464-3391
dc.identifier.urihttp://hdl.handle.net/10400.1/13234
dc.language.isoeng
dc.peerreviewedyes
dc.publisherPergamon-Elsevier Science Ltd
dc.relationCoimbra Chemistry Center
dc.subjectFriedel-crafts reactions
dc.subjectEnantioselective synthesis
dc.subjectBis-indolylmethanes
dc.subjectRecyclable catalyst
dc.subjectCarbonyl-compounds
dc.subjectTerminal alkynes
dc.subjectIndoles
dc.subjectDerivatives
dc.subjectNitrosoalkenes
dc.subjectActivation
dc.titleHetero-Diels-Alder approach to Bis(indolyl)methanes
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCoimbra Chemistry Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00313%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00313%2F2013/PT
oaire.citation.endPage1131
oaire.citation.issue3
oaire.citation.startPage1122
oaire.citation.titleBioorganic & Medicinal Chemistry
oaire.citation.volume25
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream5876
person.familyNameGrosso
person.familyNameRodrigues
person.familyNameMarques
person.familyNameBarreira
person.familyNameLemos
person.givenNameCarla
person.givenNameMaria João
person.givenNameCátia F.
person.givenNameLuísa
person.givenNameAmerico
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person.identifier.ridS-6768-2017
person.identifier.ridB-4892-2008
person.identifier.scopus-author-id25229731200
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id57192868264
person.identifier.scopus-author-id11139694000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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