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Advances in Pancreatic Cancer treatment by Nano-Based drug delivery systems

2023-09-21Journal article Open access
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dc.contributor.authorViegas, Cláudia
dc.contributor.authorPatrício, Ana B.
dc.contributor.authorPrata, João
dc.contributor.authorFonseca, Leonor
dc.contributor.authorMacedo, Ana S.
dc.contributor.authorDuarte, Sofia O. D.
dc.contributor.authorFonte, Pedro
dc.date.accessioned2023-10-13T10:22:41Z
dc.date.available2023-10-13T10:22:41Z
dc.date.issued2023-09-21
dc.date.updated2023-09-27T12:37:30Z
dc.description.abstractPancreatic cancer represents one of the most lethal cancer types worldwide, with a 5-year survival rate of less than 5%. Due to the inability to diagnose it promptly and the lack of efficacy of existing treatments, research and development of innovative therapies and new diagnostics are crucial to increase the survival rate and decrease mortality. Nanomedicine has been gaining importance as an innovative approach for drug delivery and diagnosis, opening new horizons through the implementation of smart nanocarrier systems, which can deliver drugs to the specific tissue or organ at an optimal concentration, enhancing treatment efficacy and reducing systemic toxicity. Varied materials such as lipids, polymers, and inorganic materials have been used to obtain nanoparticles and develop innovative drug delivery systems for pancreatic cancer treatment. In this review, it is discussed the main scientific advances in pancreatic cancer treatment by nano-based drug delivery systems. The advantages and disadvantages of such delivery systems in pancreatic cancer treatment are also addressed. More importantly, the different types of nanocarriers and therapeutic strategies developed so far are scrutinized.pt_PT
dc.description.sponsorshipLA/P/0101/2020; LA/P/0140/2020;pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPharmaceutics 15 (9): 2363 (2023)pt_PT
dc.identifier.doi10.3390/pharmaceutics15092363pt_PT
dc.identifier.eissn1999-4923
dc.identifier.urihttp://hdl.handle.net/10400.1/20054
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationInstitute for Bioengineering and Biosciences
dc.relationInstitute for Bioengineering and Biosciences
dc.relationAntibody encapsulation into polymer nanoparticles as a promising strategy for lung cancer treatment
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPancreatic cancerpt_PT
dc.subjectPolymer nanoparticlept_PT
dc.subjectLipid nanoparticlept_PT
dc.subjectHybrid nanoparticlept_PT
dc.subjectInorganic nanoparticlept_PT
dc.subjectNanocarrierpt_PT
dc.titleAdvances in Pancreatic Cancer treatment by Nano-Based drug delivery systemspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleAntibody encapsulation into polymer nanoparticles as a promising strategy for lung cancer treatment
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04565%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04565%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/2020.08839.BD/PT
oaire.citation.issue9pt_PT
oaire.citation.startPage2363pt_PT
oaire.citation.titlePharmaceuticspt_PT
oaire.citation.volume15pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
person.familyNameMestre Viegas
person.familyNameFonte
person.givenNameCláudia Sofia
person.givenNamePedro
person.identifier.ciencia-idBC13-CBFD-ECA6
person.identifier.ciencia-id2410-123D-3385
person.identifier.orcid0000-0001-6668-2778
person.identifier.orcid0000-0002-1115-9282
person.identifier.ridK-3215-2013
person.identifier.scopus-author-id55146900200
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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