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NF-kappa B-dependent RANKL expression in a mouse model of immature T-cell leukemia

2019-03Journal article Open access
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dc.contributor.authorFernandes, Mónica T
dc.contributor.authorCaroco, Lara S.
dc.contributor.authorPacheco-Leyva, Ivette
dc.contributor.authorR. dos Santos, Nuno
dc.date.accessioned2020-07-24T10:52:42Z
dc.date.available2020-07-24T10:52:42Z
dc.date.issued2019-03
dc.description.abstractActivation of the receptor activator of nuclear factor-kappa B (RANK) by its ligand (RANKL) is involved in both solid and hematological malignancies, including multiple myeloma, acute myeloid leukemia and B-cell leukemia. Although RANKL expression has been described in normal T cells, a potential role in T-cell leukemia remains undefined. Here, we used a model of immature T-cell leukemia/lymphoma, the TEL-JAK2 transgenic mice, to assess RANKL expression in leukemic cells and its regulatory mechanisms. We found that Rankl mRNA was significantly overexpressed in leukemic T cells when compared to wild-type thymocytes, their nonmalignant counterparts. Moreover, Rankl mRNA and RANKL surface expression in leukemic cells was induced by T-cell receptor (TCR) signaling activation, dependently on the NFKB signaling pathway. These results indicate that TCR-activated leukemic T cells express high levels of RANKL and are potential inducers of RANK signaling in microenvironmental cells. (C) 2019 Elsevier Inc. All rights reserved.
dc.description.sponsorshipFundacao para a Ciencia e a Tecnologia (Portugal)Portuguese Foundation for Science and Technology [PTDC/SAU-OBD/103336/2008, UID/BIM/04773/2013, POCI-01-0145-FEDER-007274, SFRH/BD/75137/2010, IF/00056/2012]
dc.description.sponsorshipEuropean Regional Development Fund through COMPETE 2020 programEuropean Union (EU) [NORTE-01-0145-FEDER-000029]
dc.identifier.doi10.1016/j.bbrc.2019.01.089
dc.identifier.issn0006-291X
dc.identifier.issn1090-2104
dc.identifier.urihttp://hdl.handle.net/10400.1/14394
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAcademic Press Inc Elsevier Science
dc.subjectFactor receptor family
dc.subjectOsteoclast differentiation
dc.subjectOsteoprotegerin-ligand
dc.subjectEpithelial-cells
dc.subjectActivator
dc.subjectCytokine
dc.subjectTrance
dc.subjectGrowth
dc.subjectMember
dc.subjectMechanisms
dc.titleNF-kappa B-dependent RANKL expression in a mouse model of immature T-cell leukemia
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage277
oaire.citation.issue2
oaire.citation.startPage272
oaire.citation.titleBiochemical and Biophysical Research Communications
oaire.citation.volume510
person.familyNameTeotónio Fernandes
person.familyNamePacheco-Leyva
person.familyNameRodrigues dos Santos
person.givenNameMónica Alexandra
person.givenNameIvette
person.givenNameNuno
person.identifier.ciencia-idD21D-88F0-DBD1
person.identifier.ciencia-idB812-0D5C-4983
person.identifier.orcid0000-0002-1206-1367
person.identifier.orcid0000-0003-3006-2264
person.identifier.orcid0000-0001-7347-2592
person.identifier.scopus-author-id56524572200
person.identifier.scopus-author-id7006810054
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication4aeefcfb-528b-4067-95ed-fef9aacccebf
relation.isAuthorOfPublication05f53caf-f970-4858-8135-03a9398c5512
relation.isAuthorOfPublicationcd54e8ca-80e4-49d1-8fa1-d275fc51ddb2
relation.isAuthorOfPublication.latestForDiscoverycd54e8ca-80e4-49d1-8fa1-d275fc51ddb2

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