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Coordination of deiodinase and thyroid hormone receptor expression during the larval to juvenile transition in sea bream (Sparus aurata, Linnaeus)

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dc.contributor.authorCampinho, Marco António
dc.contributor.authorGalay-Burgos, M.
dc.contributor.authorSweeney, Glen E.
dc.contributor.authorPower, Deborah
dc.date.accessioned2014-10-23T09:20:42Z
dc.date.available2014-10-23T09:20:42Z
dc.date.issued2010
dc.description.abstractTo test the hypothesis that THs play an important role in the larval to juvenile transition in the marine teleost model, sea bream (Sparus auratus), key elements of the thyroid axis were analysed during development. Specific RT-PCR and Taqman quantitative RT-PCR were established and used to measure sea bream iodothyronine deiodinases and thyroid hormone receptor (TR) genes, respectively. Expression of deiodinases genes (D1 and D2) which encode enzymes producing T3, TRs and T4 levels start to increase at 20–30 days post-hatch (dph; beginning of metamorphosis), peak at about 45 dph (climax) and decline to early larval levels after 90–100 dph (end of metamorphosis) when fish are fully formed juveniles. The profile of these different TH elements during sea bream development is strikingly similar to that observed during the TH driven metamorphosis of flatfish and suggests that THs play an analogous role in the larval to juvenile transition in this species and probably also in other pelagic teleosts. However, the effect of T3 treatment on deiodinases and TR transcript abundance in sea bream is not as clear cut as in larval flatfish and tadpoles indicating divergence in the responsiveness of TH axis elements and highlighting the need for further studies of this axis during development of fish.por
dc.description.sponsorshipWorkco-financed by POCI 2010 and European social funds attributed by the Portuguese National Science and Technology Foundation (FCT) to project POCTI/CVT/38703/2001, a Pluriannual project to CCMAR and a PhD fellowship to MAC (SFRH/BD/6133/2001).por
dc.identifier.citationMarco António Campinho, Malyka Galay-Burgos, Glen E. Sweeney, Deborah Mary Power. Coordination of deiodinase and thyroid hormone receptor expression during the larval to juvenile transition in sea bream (Sparus aurata, Linnaeus). General and Comparative Endocrinology 165 (2010) 181–194.por
dc.identifier.doihttp://dx.doi.org/10.1016/j.ygcen.2009.06.020
dc.identifier.issn0016-6480
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5418
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectThyroid hormonespor
dc.subjectDeiodinasespor
dc.subjectThyroid hormone receptorspor
dc.subjectLarval to juvenile transitionpor
dc.subjectSea breampor
dc.titleCoordination of deiodinase and thyroid hormone receptor expression during the larval to juvenile transition in sea bream (Sparus aurata, Linnaeus)por
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage194por
oaire.citation.startPage181por
oaire.citation.titleGeneral and Comparative Endocrinologypor
oaire.citation.volume165por
person.familyNameCampinho
person.familyNamePower
person.givenNameMarco António
person.givenNameDeborah Mary
person.identifier.ciencia-id0E18-2560-6EC1
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-5238-0506
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridD-8833-2013
person.identifier.scopus-author-id8938999600
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

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