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Discriminative influence of persistent organic pollutants on nesting green sea turtles through genotoxicity, oxidative stress and reproductive related markers

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dc.contributor.authorMorão, Inês F. C.
dc.contributor.authorMuñoz-Arnanz, Juan
dc.contributor.authorSimões, Tiago
dc.contributor.authorBartalini, Alice
dc.contributor.authorVieira, Sara
dc.contributor.authorFerreira-Airaud, Betânia
dc.contributor.authorCaliani, Ilaria
dc.contributor.authorNoi, Agata Di
dc.contributor.authorCasini, Silvia
dc.contributor.authorFossi, Maria Cristina
dc.contributor.authorJiménez, Begoña
dc.contributor.authorLemos, Marco F. L.
dc.contributor.authorNovais, Sara C.
dc.date.accessioned2026-01-07T12:50:00Z
dc.date.available2026-01-07T12:50:00Z
dc.date.issued2025
dc.description.abstractPersistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochloride pesticides (OCPs) affect biodiversity by bioaccumulating through food webs, impacting marine organisms like endangered sea turtles. This study represents the first evaluation of these contaminants in sea turtles nesting in São Tomé and Príncipe. The main goal was to evaluate PCBs, PBDEs and OCPs levels in sea turtles’ blood and investigate their potential effects on erythrocytic nuclear abnormalities (ENAs) and oxidative stress and reproduction-related gene expression. The relative mean abundance for contaminants was ΣPCBs > ΣOCPs > ΣPBDEs. Contaminants such as PCB-28, PCB-138, PCB-153, PCB-180 and p,p’- DDE were associated with ENAs, suggesting potential genetic instability and cellular disruption. PCB-126, PBDE100, and o,p’-DDD correlated with antioxidant and detoxification genes (glrx3, gst, txnip, txnrd2, and gclc), suggesting oxidative stress responses. The reproduction-related gene est17 was correlated with α- and β-HCH, potentially affecting ovary development. Correlations between ace2 and various PCBs, PBDEs, and o,p′-DDD suggest disruptions in follicular development and egg transport. Embryo development genes (hoxA1 and tuba1) were associated with PBDE-154, PBDE-100 and o,p’-DDD, suggesting possible embryonic alterations. These findings highlight the impacts of POPs on nesting female green turtles in São Tomé, threatening this endangered population.eng
dc.description.sponsorshipPD/BD/150562/2019; CEECIND/CP1671/CT0001; CEECINST/00060/2021/CP2799/CT0007
dc.identifier.doi10.1016/j.jhazmat.2025.139762
dc.identifier.issn0304-3894
dc.identifier.urihttp://hdl.handle.net/10400.1/28064
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationAquatic Research Infrastructure Network
dc.relation.ispartofJournal of Hazardous Materials
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPCBs
dc.subjectPBDEs
dc.subjectOCPs
dc.subjectTEQ values
dc.subjectOxidative stress
dc.subjectReproduction
dc.titleDiscriminative influence of persistent organic pollutants on nesting green sea turtles through genotoxicity, oxidative stress and reproductive related markerseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAquatic Research Infrastructure Network
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0069%2F2020/PT
oaire.citation.startPage139762
oaire.citation.titleJournal of Hazardous Materials
oaire.citation.volume498
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameVieira
person.familyNameFerreira-Airaud
person.givenNameSara
person.givenNameBetânia
person.identifier.orcid0000-0001-6113-1862
person.identifier.orcid0000-0002-2874-1367
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication73f56099-e152-4991-980f-280d42081ec9
relation.isAuthorOfPublicationc2275039-b13c-47a9-bf82-548693f2996e
relation.isAuthorOfPublication.latestForDiscovery73f56099-e152-4991-980f-280d42081ec9
relation.isProjectOfPublication5af011f9-3888-449a-a18c-d08b59e87091
relation.isProjectOfPublication.latestForDiscovery5af011f9-3888-449a-a18c-d08b59e87091

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